breast cancer cells

[Proceedings of the National Academy of Sciences of the United States of America] Treatment of breast cancer cells with a small-molecule inhibitor of BRD4, JQ1, resulted in no immediate activation of the drug-resistant genes, but long-time treatment or destabilization of LSD1 by PELI1 decommissioned the BRD4/LSD1/NuRD complex.

[Cell Death & Disease] ADRB3 promoted metastasis by inducing mobilization and inhibiting differentiation of both breast cancer cells and myeloid-derived suppressor cells.

[Cell Death & Disease] Knockout of diacylglycerol kinase ζ (DGKZ) in TNBC cell lines were found to significantly inhibit metastatic behaviors in vitro and in vivo, whereas its overexpression increased the metastatic potential of cell lines.

[Biochemical and Biophysical Research Communications] Scientists observed an increased level of EMT markers in CSC population. Overexpression of secretory phospholipase sPLA2-IIA was found in CSCs.

[Advanced Healthcare Materials] Researchers used a recently developed composite hydrogel composed of a fibrin matrix and phase-shift emulsion, termed an acoustically-responsive scaffold, to investigate effects of local mechanical properties on breast cancer cell signaling.

[Journal of Cellular Physiology] Ubiquitin-specific peptidase 5 (USP5) stabilized hypoxia-inducible factor 2α (HIF2α) through its deubiquitinase activity and provided a potential therapeutic target for breast cancer.