breast cancer cells

[Clinical Cancer Research] Old and young mouse brains, metastatic and naïve, were analyzed by flow cytometry. Immune populations were depleted using antibodies or a colony stimulating factor-1 receptor (CSF-1R) inhibitor, and brain metastasis assays were conducted.

[Molecular Cancer Research] To understand how 223RaCl2, an alpha particle emitting radiopharmaceutical, affects the growth delay of disseminated tumor cells, scientists quantified the biological changes caused by direct effects of radiation and bystander effects caused by the emitted radiations on mammary tumor cells.

[Cancers] Researchers demonstrated that long non-coding RNA prostate androgen regulated transcript 1 (PART1) was enriched in TNBCs. Knockdown of PART1 in TNBC cell lines and a patient-derived xenograft decreased cell proliferation, migration, tumor growth, and mammosphere formation potential.

[Cell Systems] Pooled fitness screens in two breast cancer cell lines revealed peptides, which selectively reduced cellular proliferation, implicating oncogenic protein domains important for cell fitness.

[Scientific Reports] Scientists studied the biological function of cytoplasmic maspin in breast cancer cell lines. Subcellular localization of maspin in MDA-MB-231 breast cancer cells was mainly detected in the cytoplasm, whereas in MCF10A mammary epithelial cells, maspin was present in both cytoplasm and nucleus.

[Cell Reports] Scientists established RBM39/MLL1 as a major contributor to the abnormal epigenetic landscape in breast cancer and laid the foundation for peptide-mediated cancer-specific therapy based on disruption of RBM39 epigenomic functions.