breast cancer

[Molecular Biology Reports] Plate clone formation assay was performed to detect the effect of kaempferol on cell proliferation. Flow cytometry was used to detect the impact of kaempferol on cell apoptosis and cell cycle distribution.

[Molecular Therapy] Scientists found that doxorubicin treatment significantly induced RNA m6A methylation in breast cancer cells in both a dose- and time-dependent manner.

[Cell Death & Disease] YTHDF1 facilitated S-phase entry, DNA replication and DNA damage repair, and accordingly YTHDF1 knockdown sensitized breast cancer cells to Adriamycin and Cisplatin as well as Olaparib, a PARP inhibitor.

[Scientific Reports] Investigators found that the zinc complex of 3,5-di-tert-butyl salicylate compound inhibited viability, invasion, and migration and induced apoptosis in triple-negative breast cancer 4T1 cells.

[Biochemical Genetics] Circular RNA-trefoil factor 1 (circ-TFF1) and interleukin-1 receptor-associated kinase 1 (IRAK1) were significantly high expressed in breast cancer tissues and cells. Silencing of circ-TFF1 reduced the proliferation, migration, invasion and tube formation, while increased the apoptosis of MDA-MB-361 and SK-Br-3 cells.

[Cell Death & Differentiation] The mechanisms underlying MYC deubiquitination in breast cancer were not well defined. Researchers reported that OTUB1 was responsible for MYC deubiquitination.