breast cancer

[Cell Death & Disease] Investigators reported that RNF187, a RING family ubiquitin ligase, facilitated breast cancer growth and inhibited apoptosis by modulating P53 signaling.

[BriaCell, Inc.] BriaCell Therapeutics Corp. announced the appointment of Giuseppe Del Priore, MD, MPH, as the Company's Chief Medical Officer, effective today.

[Biophysical Journal] Researchers found that in addition to increased cell motility, cancer cells exploited the elevated actomyosin force generation to remodel ECM and to deplete important co-stimulatory receptors on antigen presenting cells, facilitating tumor progression.

[Nature Cell Biology] The authors found that a soft ECM empowered redox homeostasis. Cells cultured on a soft ECM displayed increased peri-mitochondrial F-actin, promoted by Spire1C and Arp2/3 nucleation factors, and increased DRP1- and MIEF1/2-dependent mitochondrial fission.

[Oncogene] CircKDM4B inhibited migration and tube formation of HUVECs in vitro and angiogenesis in vivo.

[International Journal of Biological Macromolecules] Disulfiram (DS)@CA/PEO nanofiber scaffold showed higher safety than DS-free on human normal cells with revealing similar anticancer activity of DS-free against colon cancer line and breast cancer line.