breast cancer

[Oncogene] The authors report the prognostic value, clinical relevance, and biological significance of the Nischarin gene in breast cancer patients using the Molecular Taxonomy of Breast Cancer International Consortium and The Cancer Genome Atlas datasets.

[CNS Drugs] HER2-targeted therapies, including antibody-drug conjugates, have presented new therapeutic options for this patient population; however, additional data for both small-molecule inhibitors and antibody-drug conjugates with respect to patients with central nervous system metastases is needed. Scientists specifically review the data for the management of HER2+ parenchymal brain metastases.

[Breast Cancer Research] Keratin 13 (KRT13) plays an important role in breast cancer progression and metastasis. Researchers elucidated the mechanism by which KRTs promoted breast cancer growth and metastasis.

[Cellular & Molecular Immunology] Scientists reported that dedicator of cytokinesis 2 (DOCK2) promoted indispensable antifungal innate immune signaling and proinflammatory gene expression in macrophages.

[Cellular and Molecular Life Sciences] The authors review the clinical significance of mesenchymal circulating tumor cells (CTCs) in breast cancer together with statistical analysis of previously published data, in which they assess the suitability of a number of methods/markers used for isolation of CTCs with different epithelial-mesenchymal transition phenotypes.

[Toxicology and Applied Pharmacology] Researchers used Kaempferol in combination with Verapamil, in multiple assays to determine if there was an inhibitory effect on breast cancer stem cells.