breast cancer

[Experimental & Molecular Medicine] Scientists found that melatonin synergized with doxorubicin to induce apoptosis of breast cancer cells by decreasing the expression of AMP-activated protein kinase α1 (AMPK α1), which acted as a critical survival factor for cancer cells.

[Oncogene] Scientists investigated the loss of SOX4 in mammary tumor development utilizing organoids derived from a PyMT genetic mouse model of breast cancer.

[Experimental & Molecular Medicine] Lung metastasis and endothelial function were analyzed together with blood nucleotides, plasma amino acids, nicotinamide metabolites, and vascular ectoenzymes of nucleotide catabolism.

[Communications Biology] By using high-dimensional single-cell technologies, scientists identified heterogeneous behavior within the tissue-resident memory CD8+ T cells infiltrating luminal-like tumors.

[Clinical Cancer Research] Using inducible-shRNAs in TNBC and HER2+ breast-brain metastatic models researchers assessed IL13Rα2 function in vitro and in vivo.

[Accutar Biotechnology, Inc.] Accutar Biotechnology, Inc. announced that the FDA has cleared the company’s investigational new drug application (IND) for AC0682 for the treatment of patients with estrogen receptor (ER)-positive breast cancers.