Cancer-Initiating Cells in Human Pancreatic Cancer Organoids Are Maintained by Interactions with Endothelial Cells

Organoid-derived CD44(−) cancer cells were capable of organoid re-formation and could be re-programed as CD44-expressing cancer-initiating cells in the organoid culture system.
[Cancer Letters]
Choi, J.-I., Jang, S. I., Hong, J., Kim, C. H., Kwon, S. S., Park, J. S., & Lim, J.-B. (2020). Cancer-initiating cells in human pancreatic cancer organoids are maintained by interactions with endothelial cells. Cancer Letters. https://doi.org/10.1016/j.canlet.2020.10.012 Cite
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The Role of Breast Cancer Stem Cell-Related Biomarkers as Prognostic Factors

The cell-surface and subcellular biomarkers related to breast cancer stem cell (BCSC) phenotypes are increasingly being recognised. These biomarkers are useful for the isolation of BCSCs and can serve as potential therapeutic targets and prognostic tools to monitor treatment responses.
[Diagnostics ]
Ko, C. C. H., Chia, W. K., Selvarajah, G. T., Cheah, Y. K., Wong, Y. P., & Tan, G. C. (2020). The Role of Breast Cancer Stem Cell-Related Biomarkers as Prognostic Factors. Diagnostics, 10(9), 721. https://doi.org/10.3390/diagnostics10090721 Cite
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Development of an Artificial Antibody Specific for HLA/Peptide Complex Derived from Cancer Stem-Like Cell/Cancer-Initiating Cell Antigen DNAJB8

Investigators developed a therapeutic single-chain variable-fragment antibody that recognises the cancer stem-like cell/cancer-initiating cell antigen, DNAJB8.
[British Journal of Cancer]
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