cancer initiating cells

[Cell] Scientists reported that glycogen accumulation was a key initiating oncogenic event during liver malignant transformation, and found that glucose-6-phosphatase catalyzing the last step of glycogenolysis was frequently downregulated to augment glucose storage in pre-malignant cells.

[Cell Death & Disease] Scientists delineate the key factors in pancreatic ductal adenocarcinoma derived extracellular vesicles that mediate different tumour processes.

[Molecular Cancer] CircIPO11 was highly expressed in hepatocellular carcinoma (HCC) tumor tissues and liver cancer stem cells (CSCs), and was required for the self-renewal maintenance of liver CSCs to initiate HCC development.

[Journal of Immunology] The authors discovered that the expression of P2Y6 was decreased upon the activation of the NK cells. In the P2Y6-deficient mice, scientists found that the deficiency of P2Y6 promoted the development of the NK precursor cells into immature NK and mature NK cells.

[Cancer Immunology Immunotherapy] Investigators established a novel bladder CSC/cancer-initiating cells (CICs) model from a bladder cancer cell line using an ALDEFLUOR assay. CSCs/CICs were isolated as aldehyde dehydrogenase (ALDH)-high cells and several aldehyde dehydrogenasehigh clone cells were established.

[Stem Cell Reviews and Reports] Scientists describe cancer-initiating cells' (CICs) contribution to cancer progression.