cancer stem cells

[GenFleet Therapeutics] GenFleet Therapeutics announced the first patient with metastatic sigmoid adenocarcinoma has been dosed in a Phase Ib/II trial of GFH018 in combination with toripalimab as part of global multi-center clinical research. There are broad indications for GFH018 in treating solid tumors with lower response rates to PD-1 inhibitors.

[Cell Death & Disease] Researchers showed that high LSD1 expression was a predictor of poor prognosis for head and neck squamous cell carcinoma patients. They found that high expression of LSD1 was essential for the maintenance of the CSC properties by regulating Bmi-1 expression.

[Cell Death & Disease] Cancer stem-like cells drive tumorigenesis and progression of head and neck squamous cell carcinoma (HNSCC). Scientists observed that high Bmi-1 expression correlated with decreased recurrence-free survival time in HNSCC patients

[Experimental Cell Research] Researchers analyzed carnitine palmitoyltransferase 2 (CPT2) expression in colorectal cancer (CRC) tissues and cells. CPT2 was overexpressed in CRC cell lines, and its effects and molecular mechanism on the proliferation, glycolysis, stemness, and oxaliplatin sensitivity were investigated.

[Cell Death & Disease] The authors used the breast cancer mouse model MMTV-PyMT, and constructed a single-cell atlas of 31,778 cells from four distinct stages of tumor progression, during which malignant transition occured.

[Oncogene] Using several in vitro and in vivo models lacking C1GALT1 expression, investigators identified the role of aberrant O-glycosylation in stemness properties and aggressive pancreatic cancer metastasis.