Targeting LSD1 Suppresses Stem Cell-Like Properties and Sensitizes Head and Neck Squamous Cell Carcinoma to PD-1 Blockade

Researchers showed that high LSD1 expression was a predictor of poor prognosis for head and neck squamous cell carcinoma patients. They found that high expression of LSD1 was essential for the maintenance of the CSC properties by regulating Bmi-1 expression.