cardiac fibroblasts

[Scientific Reports] Researchers leveraged adeno-associated virus (AAV) to target cardiac fibroblasts and demonstrated that chronic Yes-associated protein (YAP) expression upregulated indices of fibrosis and inflammation in the absence of additional stress.

[Scientific Reports] Scientists used human induced pluripotent stem cell-derived cardiomyocytes and human cardiac fibroblasts in 3-dimensional microtissues to create an improved in vitro platform for assessing pro-arrhythmic cardiotoxicity.

[Experimental and Molecular Medicine] Under hypoxic conditions, the authors observed that ASCmiR-210 inhibited apoptosis by modulating protein tyrosine phosphatase 1B and death-associated protein kinase 1.

[Circulation Research] Scientists demonstrated that salinomycin displayed potent anti-fibrotic activity in cardiac fibroblasts obtained from heart failure patients. In pre-clinical studies, salinomycin prevented cardiac fibrosis and functional decline in mouse models of ischemic and non-ischemic heart disease.

[Nature Protocols] Scientists describe a protocol to generate cardiomyocytes, cardiac fibroblasts and cardiac endothelial cells, the three principal cell types in the heart, from human induced pluripotent stem cells and combine them in 3D cardiac microtissues.

[Science Translational Medicine] Investigators observed improved cardiac function, enhanced vascular density, and smaller infarct size in mice treated with the small extracellular vesicles from hypoxia-preconditioned mesenchymal stem cells (MSCs) than in mice treated with normoxia-preconditioned MSCs.