cardiomyocytes

[Aging Cell] Investigators demonstrated that deficiency of SIRT1 and SIRT3 in aged mice hearts led to the exacerbated cardiac dysfunction in terms of cardiac systolic dysfunction, cardiomyocytes contractile defection, and abnormal cardiomyocyte calcium flux during ischemia/reperfusion stress.

[Journal of Cachexia Sarcopenia and Muscle] Scientists employed 15- to 16-month-old female and male Ahnak1-knockout and wild-type mice and performed morphometric, biochemical, and bioenergetics assays to evaluate the effects of Ahnak1 on exercise capacity and mitochondrial morphology and function in cardiomyocytes and tibialis anterior muscle.

[Seminars in Cell & Developmental Biology] Over the last decade, remarkable progresses have been made on cardiac reprogramming, particularly focusing on how to enhance conversion of fibroblasts to induced cardiomyocyte-like cells in vitro. The author discusses progresses and challenges of cardiac reprogramming in the translational context.

[Cell Death & Disease] Scientists optimized a protocol to generate chemically defined human induced pluripotent stem cell-derived mesodermal progenitors and they demonstrate that these cells contributed to myotube formation and differentiated into cardiomyocyte.

[Journal of Cellular Physiology] Scientists challenged ventricular cardiomyocytes with epidermal growth factor (EGF)-like ligands and observed that selective activation of ErbB4 (the receptor for neuregulin 1), but not ErbB1 (the receptor for EGF), stimulated hypertrophy.

[Life Sciences] The authors summarize the current knowledge on the cardiac signaling pathways modulated by two antineoplastic drugs highly used in the management of breast cancer, not only focusing on cardiomyocytes but also to broaden the knowledge of the potential impact on other cells found in the heart.