Age-Related Decline in Murine Heart and Skeletal Muscle Performance Is Attenuated by Reduced Ahnak1 Expression

Scientists employed 15- to 16-month-old female and male Ahnak1-knockout and wild-type mice and performed morphometric, biochemical, and bioenergetics assays to evaluate the effects of Ahnak1 on exercise capacity and mitochondrial morphology and function in cardiomyocytes and tibialis anterior muscle.