Stimulation of the Four Isoforms of Receptor Tyrosine Kinase ErbB4, but Not ErbB1, Confers Cardiomyocyte Hypertrophy

Scientists challenged ventricular cardiomyocytes with epidermal growth factor (EGF)-like ligands and observed that selective activation of ErbB4 (the receptor for neuregulin 1), but not ErbB1 (the receptor for EGF), stimulated hypertrophy.