cardiomyocytes

[Scientific Reports] The authors investigated the role of late sodium current conductance in arrhythmias using adult primary cardiomyocytes and tissues from donor hearts.

[Scientific Reports] Researchers investigated the dominant rule determining synchronization of beating intervals of cardiomyocytes after the clustering of mouse primary and human embryonic stem cell-derived cardiomyocytes.

[Molecular Therapy-Methods & Clinical Development] Scientists devised a single cut gene editing method using a compact Staphylococcus aureus Cas9 to restore the open reading frame of exon 51, the most commonly affected out-of-frame exon in Duchenne muscular dystrophy. Editing of exon 51 in cardiomyocytes revealed a strong preference for exon reframing via a two nucleotide deletion.

[Scientific Reports] Investigators identified a new compound that inhibited reactive oxygen species production in isolated mouse cardiomyocytes and improved cardiomyocyte contractility and contraction of whole retrogradely perfused hearts after a global ischemia period.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists employed highly sensitive fluorescence spectroscopy approaches, in combination with a fluorescent β‐AR antagonist, to determine the presence and dynamics of the endogenous receptors on the outer plasma membrane as well as on the T-tubular network of intact adult cardiomyocytes.

[Scientific Reports] Researchers explored the association between sitting patterns and microRNAs isolated from endothelial cell-derived extracellular vesicles.