Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell NewsResearchers explored the association between sitting patterns and microRNAs isolated from endothelial cell-derived extracellular vesicles.
[Scientific Reports]
6445218 {6445218:GR5ZKVU4} apa 50 1 163080 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-bc5979a89a64d8548dc0675a0113b7f9%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22GR5ZKVU4%22%2C%22library%22%3A%7B%22id%22%3A6445218%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Chang%20et%20al.%22%2C%22parsedDate%22%3A%222021-06-03%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EChang%2C%20Y.-J.%2C%20Tuz-Zahra%2C%20F.%2C%20Godbole%2C%20S.%2C%20Avitia%2C%20Y.%2C%20Bellettiere%2C%20J.%2C%20Rock%2C%20C.%20L.%2C%20Jankowska%2C%20M.%20M.%2C%20Allison%2C%20M.%20A.%2C%20Dunstan%2C%20D.%20W.%2C%20Rana%2C%20B.%2C%20Natarajan%2C%20L.%2C%20%26amp%3B%20Sears%2C%20D.%20D.%20%282021%29.%20Endothelial-derived%20cardiovascular%20disease-related%20microRNAs%20elevated%20with%20prolonged%20sitting%20pattern%20among%20postmenopausal%20women.%20%3Ci%3EScientific%20Reports%3C%5C%2Fi%3E%2C%20%3Ci%3E11%3C%5C%2Fi%3E%281%29%2C%2011766.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-021-90154-1%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-021-90154-1%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445218%26amp%3Bitem_key%3DGR5ZKVU4%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Endothelial-derived%20cardiovascular%20disease-related%20microRNAs%20elevated%20with%20prolonged%20sitting%20pattern%20among%20postmenopausal%20women%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ya-Ju%22%2C%22lastName%22%3A%22Chang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fatima%22%2C%22lastName%22%3A%22Tuz-Zahra%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Suneeta%22%2C%22lastName%22%3A%22Godbole%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yesenia%22%2C%22lastName%22%3A%22Avitia%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22John%22%2C%22lastName%22%3A%22Bellettiere%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cheryl%20L.%22%2C%22lastName%22%3A%22Rock%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marta%20M.%22%2C%22lastName%22%3A%22Jankowska%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthew%20A.%22%2C%22lastName%22%3A%22Allison%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%20W.%22%2C%22lastName%22%3A%22Dunstan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Brinda%22%2C%22lastName%22%3A%22Rana%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Loki%22%2C%22lastName%22%3A%22Natarajan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dorothy%20D.%22%2C%22lastName%22%3A%22Sears%22%7D%5D%2C%22abstractNote%22%3A%22Time%20spent%20sitting%20is%20positively%20correlated%20with%20endothelial%20dysfunction%20and%20cardiovascular%20disease%20risk.%20The%20underlying%20molecular%20mechanisms%20are%20unknown.%20MicroRNAs%20contained%20in%20extracellular%20vesicles%20%28EVs%29%20reflect%20cell%5C%2Ftissue%20status%20and%20mediate%20intercellular%20communication.%20We%20explored%20the%20association%20between%20sitting%20patterns%20and%20microRNAs%20isolated%20from%20endothelial%20cell%20%28EC%29-derived%20EVs.%20Using%20extant%20actigraphy%20based%20sitting%20behavior%20data%20on%20a%20cohort%20of%20518%20postmenopausal%20overweight%5C%2Fobese%20women%2C%20we%20grouped%20the%20woman%20as%20Interrupted%20Sitters%20%28IS%3B%20N%5Cu2009%3D%5Cu200918%29%20or%20Super%20Sitters%20%28SS%3B%20N%5Cu2009%3D%5Cu200953%29%20if%20they%20were%20in%20the%20shortest%20or%20longest%20sitting%20pattern%20quartile%2C%20respectively.%20The%20cargo%20microRNA%20in%20EC-EVs%20from%20the%20IS%20and%20SS%20women%20were%20compared.%20MicroRNA%20data%20were%20weighted%20by%20age%2C%20physical%20functioning%2C%20MVPA%2C%20device%20wear%20days%2C%20device%20wear%20time%2C%20waist%20circumference%2C%20and%20body%20mass%20index.%20Screening%20of%20CVD-related%20microRNAs%20demonstrated%20that%20miR-199a-5p%2C%20let-7d-5p%2C%20miR-140-5p%2C%20miR-142-3p%2C%20miR-133b%20level%20were%20significantly%20elevated%20in%20SS%20compared%20to%20IS%20groups.%20Group%20differences%20in%20let-7d-5p%2C%20miR-133b%2C%20and%20miR-142-3p%20were%20validated%20in%20expanded%20groups.%20Pathway%20enrichment%20analyses%20show%20that%20mucin-type%20O-glycan%20biosynthesis%20and%20cardiomyocyte%20adrenergic%20signaling%20%28P%5Cu2009%3C%5Cu20090.001%29%20are%20downstream%20of%20the%20three%20validated%20microRNAs.%20This%20proof-of-concept%20study%20supports%20the%20possibility%20that%20CVD-related%20microRNAs%20in%20EC-EVs%20may%20be%20molecular%20transducers%20of%20sitting%20pattern-associated%20CVD%20risk%20in%20overweight%20postmenopausal%20women.%22%2C%22date%22%3A%222021-06-03%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41598-021-90154-1%22%2C%22ISSN%22%3A%222045-2322%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41598-021-90154-1%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-06-03T23%3A14%3A37Z%22%7D%7D%5D%7D
Chang, Y.-J., Tuz-Zahra, F., Godbole, S., Avitia, Y., Bellettiere, J., Rock, C. L., Jankowska, M. M., Allison, M. A., Dunstan, D. W., Rana, B., Natarajan, L., & Sears, D. D. (2021). Endothelial-derived cardiovascular disease-related microRNAs elevated with prolonged sitting pattern among postmenopausal women. Scientific Reports, 11(1), 11766. https://doi.org/10.1038/s41598-021-90154-1 Cite
