cardiomyocytes

[NPJ Regenerative Medicine] The authors outline key biology-inspired strategies reported to improve cardiomyocyte maturation features and current biofabrication approaches developed to engineer clinically relevant cardiac tissues.

[Heartseed, Inc.] Heartseed Inc. and Novo Nordisk A/S announced that they have entered into a collaboration and licence agreement for the development, manufacturing and commercialisation of Heartseed’s asset HS-001, an investigational cell therapy using purified cardiomyocytes derived from induced pluripotent stem cells, which is currently under development by Heartseed for the treatment of heart failure.

[Scientific Reports] Scientists identified cell–cell and cell-ECM interactions in the microenvironment of the early four-chambered vertebrate heart that drive cardiomyocyte organization and alignment.

[Scientific Reports] Researchers investigated whether a generation of an adenovirus vectors that possess a suicide gene allow for detection of undifferentiated human iPSCs in preparations of human iPSC-derived neural progenitor cells, which have been expected to treat neurological disorders.

[Bioinformatics] Researchers used a commercial maturation medium intended to promote the maturation status of human iPSC-cardiomyocytes, and compared the parameters with the ones obtained with standard culture medium, and with freshly dissociated mouse cardiomyocytes.

[Stem Cell Reports] Researchers generated patient-specific induced pluripotent stem cell-derived atrial cardiomyocytes to characterize the pathogenesis of AF-linked SCN5A mutations.