Researchers investigated whether a generation of an adenovirus vectors that possess a suicide gene allow for detection of undifferentiated human iPSCs in preparations of human iPSC-derived neural progenitor cells, which have been expected to treat neurological disorders.
[Scientific Reports]
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Hirai, T., Kono, K., Sawada, R., Kuroda, T., Yasuda, S., Matsuyama, S., Matsuyama, A., Koizumi, N., Utoguchi, N., Mizuguchi, H., & Sato, Y. (2021). A selective cytotoxic adenovirus vector for concentration of pluripotent stem cells in human pluripotent stem cell-derived neural progenitor cells. Scientific Reports, 11(1), 11407. https://doi.org/10.1038/s41598-021-90928-7 Cite