cardiomyocytes

[Biophysical Journal] Researchers engineered a new iPSC line in which the Förster resonant energy transfer (FRET) tension sensor was knocked into the endogenous vinculin locus, which permitted consistent native levels of vinculin expression in all cells.

[Nature Cardiovascular Research] Researchers presented the transcriptional response of human cardiomyocytes to pressure overload caused by aortic valve stenosis and described major alterations in cardiac cellular crosstalk.

[Cellular Signalling] Researchers found that PH domain leucine-rich repeat protein phosphatase1 (PHLPP1) deficiency enhanced Thr163 phosphorylation of Mcl-1, inhibited Mcl-1 degradation and maintained Mcl-1 protein expression level in myocardium and cardiomyocytes upon myocardial infarction or Dox treatment.

[Biophysical Journal] Scientists engineered ribonucleotide reductase overexpressing human-induced pluripotent stem cell-derived cardiomyocytes as a novel cell therapy strategy to improve contractility and regeneration in myocardial infarction.

[Journal of Cellular Physiology] Scientists observed that apelin-13-induced cardiomyocyte hypertrophy by activating FAM134B-dependent reticulophagy via the Pannexin-1/P2X7 signal pathway.

[Life Sciences] Investigators identified the role of acyl coA synthase long chain family member 1 (ACSL1) in the regeneration of cardiomyocytes.