PHLPP1 Deficiency Ameliorates Cardiomyocyte Death and Cardiac Dysfunction through Inhibiting Mcl-1 Degradation

Researchers found that PH domain leucine-rich repeat protein phosphatase1 (PHLPP1) deficiency enhanced Thr163 phosphorylation of Mcl-1, inhibited Mcl-1 degradation and maintained Mcl-1 protein expression level in myocardium and cardiomyocytes upon myocardial infarction or Dox treatment.