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cell culture

Recent Advancement of Decellularization Extracellular Matrix for Tissue Engineering and Biomedical Application

[Artificial Organs] Investigators describe the decellularization and sterilization methods that are commonly used in recent research, and the effects of these methods upon biologic scaffold material.

Budesonide Promotes Airway Epithelial Barrier Integrity Following Double-Stranded RNA Challenge

[PLoS One] Researchers tested three classes of drugs commonly prescribed to treat asthma for their ability to promote barrier function using a cell culture model of virus-induced airway epithelial barrier disruption.

Robotic High-Throughput Biomanufacturing and Functional Differentiation of Human Pluripotent Stem Cells

[Stem Cell Reports] Investigators established a robotic platform and automated all essential steps of human iPSC culture and differentiation under chemically defined conditions.

CFTR Limits F-Actin Formation and Promotes Morphological Alignment with Flow in Human Lung Microvascular Endothelial Cells

[physiological reports] Investigators tested the hypothesis that the cystic fibrosis transmembrane conductance regulator regulated endothelial actin cytoskeleton dynamics and cellular alignment in response to flow.

Harnessing Cerebral Organoids for Alzheimer’s Disease Research

[Current Opinion in Neurobiology] Scientists review the most recent advances in modeling Alzheimer's disease in organoids and other engineered 3D cell culture systems.

Paxillin Promotes Breast Tumor Collective Cell Invasion through Maintenance of Adherens Junction Integrity

[Molecular Biology of the Cell] Scientists utilized a newly generated PyMT mammary tumor mouse model with conditional paxillin ablation in breast tumor epithelial cells, combined with in vitro 3D tumor organoids invasion analysis and 2D calcium switch assays, to assess the roles for paxillin in breast tumor cell invasion.

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