cell proliferation

[Bioscience Reports] Investigators determined the growth factors content in conditioned medium of synovial membrane MSCs (SMMSCs-CM) as well as the chondrogenic and chondroprotective markers expression in osteoarthritis model after IGF1-induced and non-induced SMMSCs-CM treatments.

[European Journal of Pharmacology] Molecular docking, cellular immunofluorescence staining, chromatin immunoprecipitation, and dual luciferase reporter assay were performed to investigate the androgenic activity of kaempferol.

[Journal of Biochemical and Molecular Toxicology] Using human vascular smooth muscle cells (VSMCs) treated by oxidized low-density lipoprotein to establish an atherosclerosis cell model, researchers explored the functional roles and molecular mechanisms of miR-141-5p in VSMCs dysfunction.

[Cell Death & Disease] Overexpressing GPR17 inhibited glioma cell proliferation and induced apoptosis by raising ROS levels. GPR17-overexpressing glioma cells are less tumorigenic in the brain than in control cells.

[Cell Death & Disease] Investigators identified Insulin gene enhancer binding protein 1 (ISL1) as an oncogene in neuroblastoma (NB). ISL1 is preferentially upregulated in NB tissues compared with normal tissues.

[Scientific Reports] Researchers identified 112 up-regulated proteins and 24 down-regulated proteins from a total of 4360 quantified proteins. GO enrichment illustrated that these proteins were mainly involved in organelle structure, catalysis, cell movement, and material metabolism.