Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell NewsOverexpressing GPR17 inhibited glioma cell proliferation and induced apoptosis by raising ROS levels. GPR17-overexpressing glioma cells are less tumorigenic in the brain than in control cells.
[Cell Death & Disease]
7753456 ZVXNNEG8 items 1 apa 0 default asc 1 163471 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-0b7efb28d34b41be5f357077e77e2005%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22ZVXNNEG8%22%2C%22library%22%3A%7B%22id%22%3A7753456%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Liu%20et%20al.%22%2C%22parsedDate%22%3A%222021-06-12%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ELiu%2C%20H.%2C%20Xing%2C%20R.%2C%20Ou%2C%20Z.%2C%20Zhao%2C%20J.%2C%20Hong%2C%20G.%2C%20Zhao%2C%20T.-J.%2C%20Han%2C%20Y.%2C%20%26amp%3B%20Chen%2C%20Y.%20%282021%29.%20G-protein-coupled%20receptor%20GPR17%20inhibits%20glioma%20development%20by%20increasing%20polycomb%20repressive%20complex%201-mediated%20ROS%20production.%20%3Ci%3ECell%20Death%20%26amp%3B%20Disease%3C%5C%2Fi%3E%2C%20%3Ci%3E12%3C%5C%2Fi%3E%286%29%2C%201%26%23x2013%3B14.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41419-021-03897-0%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41419-021-03897-0%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D7753456%26amp%3Bitem_key%3DZVXNNEG8%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22G-protein-coupled%20receptor%20GPR17%20inhibits%20glioma%20development%20by%20increasing%20polycomb%20repressive%20complex%201-mediated%20ROS%20production%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Huiqing%22%2C%22lastName%22%3A%22Liu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rui%22%2C%22lastName%22%3A%22Xing%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zhimin%22%2C%22lastName%22%3A%22Ou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Junying%22%2C%22lastName%22%3A%22Zhao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guolin%22%2C%22lastName%22%3A%22Hong%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tong-Jin%22%2C%22lastName%22%3A%22Zhao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ying%22%2C%22lastName%22%3A%22Han%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ying%22%2C%22lastName%22%3A%22Chen%22%7D%5D%2C%22abstractNote%22%3A%22Glioma%20is%20the%20most%20common%20primary%20tumor%20in%20the%20central%20nervous%20system.%20However%2C%20the%20development%20of%20glioma%20and%20effective%20therapeutic%20strategies%20remain%20elusive.%20Here%2C%20we%20identify%20GPR17%20as%20a%20potential%20target%20to%20treat%20glioma.%20Data%20mining%20with%20human%20LGG%20and%20GBM%20samples%20reveals%20that%20GPR17%20is%20negatively%20correlated%20with%20glioma%20development.%20Overexpressing%20GPR17%20inhibits%20glioma%20cell%20proliferation%20and%20induces%20apoptosis%20by%20raising%20ROS%20levels.%20GPR17-overexpressing%20glioma%20cells%20are%20less%20tumorigenic%20in%20the%20brain%20than%20in%20control%20cells.%20Mechanistically%2C%20GPR17%20inhibits%20the%20transcription%20of%20RNF2%2C%20a%20key%20component%20in%20the%20PRC1%20complex%2C%20through%20cAMP%5C%2FPKA%5C%2FNF-%5Cu03baB%20signaling%2C%20leading%20to%20reduced%20histone%20H2A%20monoubiquitination.%20ChIP-Seq%20and%20RNA-Seq%20analyses%20reveal%20KLF9%20as%20a%20direct%20target%20of%20RNF2.%20KLF9%20mediates%20the%20functions%20of%20GPR17%20and%20RNF2%20in%20glioma%20cells.%20Furthermore%2C%20activation%20of%20GPR17%20by%20its%20agonist%20inhibits%20glioma%20formation.%20Our%20findings%20have%20thus%20identified%20GPR17%20as%20a%20key%20regulator%20of%20glioma%20development%20and%20a%20potential%20therapeutic%20target%20for%20gliomas.%22%2C%22date%22%3A%222021-06-12%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41419-021-03897-0%22%2C%22ISSN%22%3A%222041-4889%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41419-021-03897-0%22%2C%22deleted%22%3A1%2C%22collections%22%3A%5B%22TUURQW3H%22%5D%2C%22dateModified%22%3A%222021-06-14T17%3A12%3A36Z%22%7D%7D%5D%7D
Liu, H., Xing, R., Ou, Z., Zhao, J., Hong, G., Zhao, T.-J., Han, Y., & Chen, Y. (2021). G-protein-coupled receptor GPR17 inhibits glioma development by increasing polycomb repressive complex 1-mediated ROS production. Cell Death & Disease, 12(6), 1–14. https://doi.org/10.1038/s41419-021-03897-0 Cite
