G-Protein-Coupled Receptor GPR17 Inhibits Glioma Development by Increasing Polycomb Repressive Complex 1-Mediated ROS Production

0
125
Overexpressing GPR17 inhibited glioma cell proliferation and induced apoptosis by raising ROS levels. GPR17-overexpressing glioma cells are less tumorigenic in the brain than in control cells.
[Cell Death & Disease]
7753456 {7753456:ZVXNNEG8} 1 apa 50 default 1 163471 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22ZVXNNEG8%22%2C%22library%22%3A%7B%22id%22%3A7753456%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Liu%20et%20al.%22%2C%22parsedDate%22%3A%222021-06-12%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BLiu%2C%20H.%2C%20Xing%2C%20R.%2C%20Ou%2C%20Z.%2C%20Zhao%2C%20J.%2C%20Hong%2C%20G.%2C%20Zhao%2C%20T.-J.%2C%20Han%2C%20Y.%2C%20%26amp%3B%20Chen%2C%20Y.%20%282021%29.%20G-protein-coupled%20receptor%20GPR17%20inhibits%20glioma%20development%20by%20increasing%20polycomb%20repressive%20complex%201-mediated%20ROS%20production.%20%26lt%3Bi%26gt%3BCell%20Death%20%26amp%3B%20Disease%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B12%26lt%3B%5C%2Fi%26gt%3B%286%29%2C%201%26%23x2013%3B14.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41419-021-03897-0%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41419-021-03897-0%26lt%3B%5C%2Fa%26gt%3B%20%26lt%3Ba%20title%3D%26%23039%3BCite%20in%20RIS%20Format%26%23039%3B%20class%3D%26%23039%3Bzp-CiteRIS%26%23039%3B%20data-zp-cite%3D%26%23039%3Bapi_user_id%3D7753456%26amp%3Bitem_key%3DZVXNNEG8%26%23039%3B%20href%3D%26%23039%3Bjavascript%3Avoid%280%29%3B%26%23039%3B%26gt%3BCite%26lt%3B%5C%2Fa%26gt%3B%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22G-protein-coupled%20receptor%20GPR17%20inhibits%20glioma%20development%20by%20increasing%20polycomb%20repressive%20complex%201-mediated%20ROS%20production%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Huiqing%22%2C%22lastName%22%3A%22Liu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rui%22%2C%22lastName%22%3A%22Xing%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zhimin%22%2C%22lastName%22%3A%22Ou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Junying%22%2C%22lastName%22%3A%22Zhao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guolin%22%2C%22lastName%22%3A%22Hong%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tong-Jin%22%2C%22lastName%22%3A%22Zhao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ying%22%2C%22lastName%22%3A%22Han%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ying%22%2C%22lastName%22%3A%22Chen%22%7D%5D%2C%22abstractNote%22%3A%22%5Cu476c%5Cu696f%5Cu6d61%5Cu2069%5Cu7320%5Cu7468%5Cu6520%5Cu6d6f%5Cu7374%5Cu2063%5Cu6f6d%5Cu6d6f%5Cu6e20%5Cu7072%5Cu696d%5Cu6172%5Cu7920%5Cu7475%5Cu6d6f%5Cu7220%5Cu696e%5Cu2074%5Cu6865%5Cu2063%5Cu656e%5Cu7472%5Cu616c%5Cu206e%5Cu6572%5Cu766f%5Cu7573%5Cu2073%5Cu7973%5Cu7465%5Cu6d2e%5Cu2048%5Cu6f77%5Cu6576%5Cu6572%5Cu2c20%5Cu7468%5Cu6520%5Cu6465%5Cu7665%5Cu6c6f%5Cu706d%5Cu656e%5Cu7420%5Cu6f66%5Cu2067%5Cu6c69%5Cu6f6d%5Cu6120%5Cu616e%5Cu6420%5Cu6566%5Cu6665%5Cu6374%5Cu6976%5Cu6520%5Cu7468%5Cu6572%5Cu6170%5Cu6575%5Cu7469%5Cu6320%5Cu7374%5Cu7261%5Cu7465%5Cu6769%5Cu6573%5Cu2072%5Cu656d%5Cu6169%5Cu6e20%5Cu656c%5Cu7573%5Cu6976%5Cu652e%5Cu2048%5Cu6572%5Cu652c%5Cu2077%5Cu6520%5Cu6964%5Cu656e%5Cu7469%5Cu6679%5Cu2047%5Cu5052%5Cu3137%5Cu2061%5Cu7320%5Cu6120%5Cu706f%5Cu7465%5Cu6e74%5Cu6961%5Cu6c20%5Cu7461%5Cu7267%5Cu6574%5Cu2074%5Cu6f20%5Cu7472%5Cu6561%5Cu7420%5Cu676c%5Cu696f%5Cu6d61%5Cu2e20%5Cu4461%5Cu7461%5Cu206d%5Cu696e%5Cu696e%5Cu6720%5Cu7769%5Cu7468%5Cu2068%5Cu756d%5Cu616e%5Cu204c%5Cu4747%5Cu2061%5Cu6e64%5Cu2047%5Cu424d%5Cu2073%5Cu616d%5Cu706c%5Cu6573%5Cu2072%5Cu6576%5Cu6561%5Cu6c73%5Cu2074%5Cu6861%5Cu7420%5Cu4750%5Cu5231%5Cu3720%5Cu6973%5Cu206e%5Cu6567%5Cu6174%5Cu6976%5Cu656c%5Cu7920%5Cu636f%5Cu7272%5Cu656c%5Cu6174%5Cu6564%5Cu2077%5Cu6974%5Cu6820%5Cu676c%5Cu696f%5Cu6d61%5Cu2064%5Cu6576%5Cu656c%5Cu6f70%5Cu6d65%5Cu6e74%5Cu2e20%5Cu4f76%5Cu6572%5Cu6578%5Cu7072%5Cu6573%5Cu7369%5Cu6e67%5Cu2047%5Cu5052%5Cu3137%5Cu2069%5Cu6e68%5Cu6962%5Cu6974%5Cu7320%5Cu676c%5Cu696f%5Cu6d61%5Cu2063%5Cu656c%5Cu6c20%5Cu7072%5Cu6f6c%5Cu6966%5Cu6572%5Cu6174%5Cu696f%5Cu6e20%5Cu616e%5Cu6420%5Cu696e%5Cu6475%5Cu6365%5Cu7320%5Cu6170%5Cu6f70%5Cu746f%5Cu7369%5Cu7320%5Cu6279%5Cu2072%5Cu6169%5Cu7369%5Cu6e67%5Cu2052%5Cu4f53%5Cu206c%5Cu6576%5Cu656c%5Cu732e%5Cu2047%5Cu5052%5Cu3137%5Cu2d6f%5Cu7665%5Cu7265%5Cu7870%5Cu7265%5Cu7373%5Cu696e%5Cu6720%5Cu676c%5Cu696f%5Cu6d61%5Cu2063%5Cu656c%5Cu6c73%5Cu2061%5Cu7265%5Cu206c%5Cu6573%5Cu7320%5Cu7475%5Cu6d6f%5Cu7269%5Cu6765%5Cu6e69%5Cu6320%5Cu696e%5Cu2074%5Cu6865%5Cu2062%5Cu7261%5Cu696e%5Cu2074%5Cu6861%5Cu6e20%5Cu696e%5Cu2063%5Cu6f6e%5Cu7472%5Cu6f6c%5Cu2063%5Cu656c%5Cu6c73%5Cu2e20%5Cu4d65%5Cu6368%5Cu616e%5Cu6973%5Cu7469%5Cu6361%5Cu6c6c%5Cu792c%5Cu2047%5Cu5052%5Cu3137%5Cu2069%5Cu6e68%5Cu6962%5Cu6974%5Cu7320%5Cu7468%5Cu6520%5Cu7472%5Cu616e%5Cu7363%5Cu7269%5Cu7074%5Cu696f%5Cu6e20%5Cu6f66%5Cu2052%5Cu4e46%5Cu322c%5Cu2061%5Cu206b%5Cu6579%5Cu2063%5Cu6f6d%5Cu706f%5Cu6e65%5Cu6e74%5Cu2069%5Cu6e20%5Cu7468%5Cu6520%5Cu5052%5Cu4331%5Cu2063%5Cu6f6d%5Cu706c%5Cu6578%5Cu2c20%5Cu7468%5Cu726f%5Cu7567%5Cu6820%5Cu6341%5Cu4d50%5Cu2f50%5Cu4b41%5Cu2f4e%5Cu462d%5Cuceba%5Cu4220%5Cu7369%5Cu676e%5Cu616c%5Cu696e%5Cu672c%5Cu206c%5Cu6561%5Cu6469%5Cu6e67%5Cu2074%5Cu6f20%5Cu7265%5Cu6475%5Cu6365%5Cu6420%5Cu6869%5Cu7374%5Cu6f6e%5Cu6520%5Cu4832%5Cu4120%5Cu6d6f%5Cu6e6f%5Cu7562%5Cu6971%5Cu7569%5Cu7469%5Cu6e61%5Cu7469%5Cu6f6e%5Cu2e20%5Cu4368%5Cu4950%5Cu2d53%5Cu6571%5Cu2061%5Cu6e64%5Cu2052%5Cu4e41%5Cu2d53%5Cu6571%5Cu2061%5Cu6e61%5Cu6c79%5Cu7365%5Cu7320%5Cu7265%5Cu7665%5Cu616c%5Cu204b%5Cu4c46%5Cu3920%5Cu6173%5Cu2061%5Cu2064%5Cu6972%5Cu6563%5Cu7420%5Cu7461%5Cu7267%5Cu6574%5Cu206f%5Cu6620%5Cu524e%5Cu4632%5Cu2e20%5Cu4b4c%5Cu4639%5Cu206d%5Cu6564%5Cu6961%5Cu7465%5Cu7320%5Cu7468%5Cu6520%5Cu6675%5Cu6e63%5Cu7469%5Cu6f6e%5Cu7320%5Cu6f66%5Cu2047%5Cu5052%5Cu3137%5Cu2061%5Cu6e64%5Cu2052%5Cu4e46%5Cu3220%5Cu696e%5Cu2067%5Cu6c69%5Cu6f6d%5Cu6120%5Cu6365%5Cu6c6c%5Cu732e%5Cu2046%5Cu7572%5Cu7468%5Cu6572%5Cu6d6f%5Cu7265%5Cu2c20%5Cu6163%5Cu7469%5Cu7661%5Cu7469%5Cu6f6e%5Cu206f%5Cu6620%5Cu4750%5Cu5231%5Cu3720%5Cu6279%5Cu2069%5Cu7473%5Cu2061%5Cu676f%5Cu6e69%5Cu7374%5Cu2069%5Cu6e68%5Cu6962%5Cu6974%5Cu7320%5Cu676c%5Cu696f%5Cu6d61%5Cu2066%5Cu6f72%5Cu6d61%5Cu7469%5Cu6f6e%5Cu2e20%5Cu4f75%5Cu7220%5Cu6669%5Cu6e64%5Cu696e%5Cu6773%5Cu2068%5Cu6176%5Cu6520%5Cu7468%5Cu7573%5Cu2069%5Cu6465%5Cu6e74%5Cu6966%5Cu6965%5Cu6420%5Cu4750%5Cu5231%5Cu3720%5Cu6173%5Cu2061%5Cu206b%5Cu6579%5Cu2072%5Cu6567%5Cu756c%5Cu6174%5Cu6f72%5Cu206f%5Cu6620%5Cu676c%5Cu696f%5Cu6d61%5Cu2064%5Cu6576%5Cu656c%5Cu6f70%5Cu6d65%5Cu6e74%5Cu2061%5Cu6e64%5Cu2061%5Cu2070%5Cu6f74%5Cu656e%5Cu7469%5Cu616c%5Cu2074%5Cu6865%5Cu7261%5Cu7065%5Cu7574%5Cu6963%5Cu2074%5Cu6172%5Cu6765%5Cu7420%5Cu666f%5Cu7220%5Cu676c%5Cu696f%5Cu6d61%5Cu732e%22%2C%22date%22%3A%222021-06-12%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41419-021-03897-0%22%2C%22ISSN%22%3A%222041-4889%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41419-021-03897-0%22%2C%22deleted%22%3A1%2C%22collections%22%3A%5B%22TUURQW3H%22%5D%2C%22dateModified%22%3A%222021-06-14T17%3A12%3A36Z%22%7D%7D%5D%7D
Liu, H., Xing, R., Ou, Z., Zhao, J., Hong, G., Zhao, T.-J., Han, Y., & Chen, Y. (2021). G-protein-coupled receptor GPR17 inhibits glioma development by increasing polycomb repressive complex 1-mediated ROS production. Cell Death & Disease, 12(6), 1–14. https://doi.org/10.1038/s41419-021-03897-0 Cite
Full Article