The authors investigated the mechanisms of action of long non-coding RNA Bmp1 on damaged intestinal mucosa. They found that Bmp1 was increased in damaged intestinal mucosal tissue and Bmp1 overexpression was able to alleviate intestinal mucosal injury.
[Cell Death & Disease]
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The authors highlight the association of several long noncoding RNAs in TNBC progression and treatment, along with their possible functions and mechanisms.
[Journal of Cellular Physiology]
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Scientists summarize the enormous amounts of findings on the signals mediating crosstalk of cancer-associated fibroblasts with cancer cells and its related targets or trials.
[Signal Transduction and Targeted Therapy]
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Researchers provided in vivo evidence that RAD51-Associated Protein 1(RAD51AP1) played a critical role in colorectal cancer (CRC) growth and drug resistance by regulating CRC stem cell self-renewal.
[Molecular Cancer Research]
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A downregulation of SNHG15 was observed in the ischemic hind limb of diabetic mice and high glucose-treated HUVECs.
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Zhu, Q., Lai, M., Chen, T., Wang, X., Tian, L., Li, D., Wu, Z., Wang, X., He, Y., He, Y., Shang, T., Xiang, Y., & Zhang, H. (2021). LncRNA SNHG15 relieves hyperglycemia-induced endothelial dysfunction via increased ubiquitination of thioredoxin-interacting protein. Laboratory Investigation, 1–11. https://doi.org/10.1038/s41374-021-00614-5 Cite
Min6 cells were induced by 5 mg/dl UA and the cell proliferation, apoptosis, and insulin release were evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, flow cytometry and glucose-stimulated insulin secretion, respectively.
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The effects of conditioned medium collected from dedifferentiated adipocytes on pancreatic cancer cell proliferation, motility, metastasis and epithelial-mesenchymal transition (EMT) were evaluated by western blot analysis, colony forming, real-time cell analysis, 5-ethynyl-2’-deoxyuridine, immunofluorescence, Transwell and wound healing assays in vitro.
[Molecular Therapy-Nucleic Acids]
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Sun, Z., Sun, D., Feng, Y., Zhang, B., Sun, P., Zhou, B., Du, L., Wang, Y., Fan, Z., Yang, J., Li, Y., Hu, S., & Zhan, H. (2021). Exosomal Linc-ROR Mediates Crosstalk between Cancer Cells and Adipocytes to Promote Tumor Growth in Pancreatic Cancer. Molecular Therapy - Nucleic Acids, 0(0). https://doi.org/10.1016/j.omtn.2021.06.001 Cite
In addition to impacting stem cell proliferation during damage-induced intestinal regeneration, the role of RAL GTPases impacted on EGFR-dependent tumorigenic growth in the intestine and in human mammary epithelium.
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Investigators reported a vapor-phased fabrication process for constructing 3D modulated scaffold materials via simple steps based on controlling mass transport of vapor sublimation and deposition.
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Investigators described the creation of a heterodimeric bifunctional fusion molecule, HCW9218, constructed using their soluble tissue factor-based scaffold technology. This complex comprised extracellular domains of the human transforming growth factor-β receptor II and a human interleukin (IL)-15/IL-15 receptor α complex.
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Liu, B., Zhu, X., Kong, L., Wang, M., Spanoudis, C., Chaturvedi, P., George, V., Jiao, J., You, L., Egan, J. O., Echeverri, C., Gallo, V. L., Xing, J., Ravelo, K., Prendes, C., Antolinez, J., Denissova, J., Muniz, G. J., Jeng, E. K., … Wong, H. C. (2021). Bifunctional TGF-β trap/IL-15 Protein Complex Elicits Potent NK Cell and CD8+ T Cell Immunity Against Solid Tumors. Molecular Therapy, 0(0). https://doi.org/10.1016/j.ymthe.2021.06.001 Cite
The endothelin-1 in the functional hydrogels significantly promoted the proliferation, migration and angiogenesis-related gene expression of human umbilical vein endothelial cells and fibroblasts.
[Journal of Materials Chemistry B]
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