Transcription Factor p53-Mediated Activation of miR-519d-3p and Downregulation of E2F1 Attenuates Prostate Cancer Growth and Metastasis

Investigators uncovered that the transcription factor p53 could upregulate miR-519d-3p expression to directly suppress the expression of E2F transcription factor 1 (E2F1), thus inhibiting prostate cancer growth and metastasis.
[Cancer Gene Therapy]
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Oxaliplatin Inhibits Angiogenin Proliferative and Cell Migration Effects in Prostate Cancer Cells

Microscopy cellular studies, carried out on the prostate cancer cell line, showed that oxaliplatin inhibited the angiogenin prompting effect on cell proliferation and migration, which were typical features of angiogenesis process.
[Journal of inorganic Biochemistry]
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Alternative Splicing of NF-YA Promotes Prostate Cancer Aggressiveness and Represents a New Molecular Marker for Clinical Stratification of Patients

Researchers indicated that the modulation of NF-YA isoforms affected prostate pathophysiological processes and contributed to a cancer-relevant phenotype, in vitro and in vivo.
[Journal of Experimental & Clinical Cancer Research]
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EGR1 Modulated LncRNA HNF1A-AS1 Drives Glioblastoma Progression via miR-22-3p/ENO1 Axis

Accumulating evidence revealed that long noncoding RNAs (lncRNAs) have been participating in cancer malignant progression, including glioblastoma multiforme (GBM). Scientists illuminated the definite mechanism of HNF1A-AS1 in promoting GBM malignancy.
[Cell Death Discovery]
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Aberrant Promoter Hypermethylation Inhibits RGMA Expression and Contributes to Tumor Progression in Breast Cancer

The authors found that RGMA was downregulated in breast cancer (BC) tissues compared with non-tumorous breast tissues, particularly in metastatic BC samples, and that patients with low RGMA expression manifested a poorer prognosis.
[Oncogene]
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MicroRNA-190b Expression Predicts a Good Prognosis and Attenuates the Malignant Progression of Pancreatic Cancer by Targeting MEF2C and TCF4

Scientists examined the expression of miR‑190b in pancreatic cancer cell lines and tissues and evaluated its effects on cancer progression.
[Oncology Reports]
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TMEM116 Is Required for Lung Cancer Cell Motility and Metastasis through PDK1 Signaling Pathway

Scientists demonstrated that transmembrane protein (TMEM) 116 was highly expressed in NSCLC tissues and cell lines.
[Cell Death & Disease]
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Nucleolar and Spindle Associated Protein 1 Enhances Chemoresistance through DNA Damage Repair Pathway in Chronic Lymphocytic Leukemia by Binding with RAD51

Researchers investigated the mechanism by which nucleolar and spindle-associated protein 1 enhanced chemoresistance via DNA damage repair signaling by stabilizing RAD51 in chronic lymphocytic leukemia cells.
[Cell Death & Disease]
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TRAF7 Contributes to Tumor Progression by Promoting Ubiquitin-Proteasome Mediated Degradation of P53 in Hepatocellular Carcinoma

Researchers discovered that TRAF7 was overexpressed in hepatocellular carcinoma tumor tissues and the increased TRAF7 expression was closely associated with tumor size, histologic grade, TNM stage and poor prognostication.
[Cell Death Discovery]
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Circ_0057583 Facilitates Brain Microvascular Endothelial Cell Injury through Modulating miR-204-5p/NR4A1 Axis

Investigators explored the potential role and mechanism of circ_0057583 in brain microvascular endothelial cell injury. Human brain microvascular endothelial cells were exposed to different doses of lipopolysaccharide to induce cell damage.
[Metabolic Brain Disease]
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Crosstalk between the Renin–Angiotensin, Complement and Kallikrein–Kinin Systems in Inflammation

The authors describe the interactive roles of the renin–angiotensin system, the complement system, and the closely linked kallikrein–kinin and contact systems in cell biological functions such as vascular tone and leakage, inflammation, chemotaxis, thrombosis and cell proliferation.
[Nature Reviews Immunology]
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