LncRNA Bmp1 Promotes the Healing of Intestinal Mucosal Lesions via the miR-128-3p/PHF6/PI3K/AKT Pathway

The authors investigated the mechanisms of action of long non-coding RNA Bmp1 on damaged intestinal mucosa. They found that Bmp1 was increased in damaged intestinal mucosal tissue and Bmp1 overexpression was able to alleviate intestinal mucosal injury.
[Cell Death & Disease]
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Long Noncoding RNAs in Triple-Negative Breast Cancer: A New Frontier in the Regulation of Tumorigenesis

The authors highlight the association of several long noncoding RNAs in TNBC progression and treatment, along with their possible functions and mechanisms.
[Journal of Cellular Physiology]
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Signaling Pathways in Cancer-Associated Fibroblasts and Targeted Therapy for Cancer

Scientists summarize the enormous amounts of findings on the signals mediating crosstalk of cancer-associated fibroblasts with cancer cells and its related targets or trials.
[Signal Transduction and Targeted Therapy]
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RAD51AP1 Loss Attenuates Colorectal Cancer Stem Cell Renewal and Sensitizes to Chemotherapy

Researchers provided in vivo evidence that RAD51-Associated Protein 1(RAD51AP1) played a critical role in colorectal cancer (CRC) growth and drug resistance by regulating CRC stem cell self-renewal.
[Molecular Cancer Research]
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LncRNA SNHG15 Relieves Hyperglycemia-Induced Endothelial Dysfunction via Increased Ubiquitination of Thioredoxin-Interacting Protein

A downregulation of SNHG15 was observed in the ischemic hind limb of diabetic mice and high glucose-treated HUVECs.
[Laboratory Investigation]
Zhu, Q., Lai, M., Chen, T., Wang, X., Tian, L., Li, D., Wu, Z., Wang, X., He, Y., He, Y., Shang, T., Xiang, Y., & Zhang, H. (2021). LncRNA SNHG15 relieves hyperglycemia-induced endothelial dysfunction via increased ubiquitination of thioredoxin-interacting protein. Laboratory Investigation, 1–11. https://doi.org/10.1038/s41374-021-00614-5 Cite
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Abnormal Expression of microRNA-296-3p in Type 2 Diabetes Patients and its Role in Pancreatic β-Cells Function by Targeting Tensin Homolog Deleted on Chromosome Ten

Min6 cells were induced by 5 mg/dl UA and the cell proliferation, apoptosis, and insulin release were evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, flow cytometry and glucose-stimulated insulin secretion, respectively.
[Biochemical Genetics]
Cheng, M., Guo, Y., Zhong, W., Chen, X., & Guo, G. (2021). Abnormal Expression of microRNA-296-3p in Type 2 Diabetes Patients and its Role in Pancreatic β-Cells Function by Targeting Tensin Homolog Deleted on Chromosome Ten. Biochemical Genetics. https://doi.org/10.1007/s10528-021-10083-6 Cite
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Exosomal Linc-ROR Mediates Crosstalk between Cancer Cells and Adipocytes to Promote Tumor Growth in Pancreatic Cancer

The effects of conditioned medium collected from dedifferentiated adipocytes on pancreatic cancer cell proliferation, motility, metastasis and epithelial-mesenchymal transition (EMT) were evaluated by western blot analysis, colony forming, real-time cell analysis, 5-ethynyl-2’-deoxyuridine, immunofluorescence, Transwell and wound healing assays in vitro.
[Molecular Therapy-Nucleic Acids]
Sun, Z., Sun, D., Feng, Y., Zhang, B., Sun, P., Zhou, B., Du, L., Wang, Y., Fan, Z., Yang, J., Li, Y., Hu, S., & Zhan, H. (2021). Exosomal Linc-ROR Mediates Crosstalk between Cancer Cells and Adipocytes to Promote Tumor Growth in Pancreatic Cancer. Molecular Therapy - Nucleic Acids, 0(0). https://doi.org/10.1016/j.omtn.2021.06.001 Cite
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RAL GTPases Mediate EGFR-Driven Intestinal Stem Cell Proliferation and Tumorigenesis

In addition to impacting stem cell proliferation during damage-induced intestinal regeneration, the role of RAL GTPases impacted on EGFR-dependent tumorigenic growth in the intestine and in human mammary epithelium.
[eLife]
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Vapor-Phased Fabrication and Modulation of Cell-Laden Scaffolding Materials

Investigators reported a vapor-phased fabrication process for constructing 3D modulated scaffold materials via simple steps based on controlling mass transport of vapor sublimation and deposition.
[Nature Communications]
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Bifunctional TGF-β Trap/IL-15 Protein Complex Elicits Potent NK Cell and CD8+ T Cell Immunity against Solid Tumors

Investigators described the creation of a heterodimeric bifunctional fusion molecule, HCW9218, constructed using their soluble tissue factor-based scaffold technology. This complex comprised extracellular domains of the human transforming growth factor-β receptor II and a human interleukin (IL)-15/IL-15 receptor α complex.
[Molecular Therapy]
Liu, B., Zhu, X., Kong, L., Wang, M., Spanoudis, C., Chaturvedi, P., George, V., Jiao, J., You, L., Egan, J. O., Echeverri, C., Gallo, V. L., Xing, J., Ravelo, K., Prendes, C., Antolinez, J., Denissova, J., Muniz, G. J., Jeng, E. K., … Wong, H. C. (2021). Bifunctional TGF-β trap/IL-15 Protein Complex Elicits Potent NK Cell and CD8+ T Cell Immunity Against Solid Tumors. Molecular Therapy, 0(0). https://doi.org/10.1016/j.ymthe.2021.06.001 Cite
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Gelatin Methacryloyl Hydrogels Functionalized with Endothelin-1 for Angiogenesis and Full-Thickness Wound Healing

The endothelin-1 in the functional hydrogels significantly promoted the proliferation, migration and angiogenesis-related gene expression of human umbilical vein endothelial cells and fibroblasts.
[Journal of Materials Chemistry B]
Li, M.-N., Yu, H.-P., Ke, Q.-F., Zhang, C.-Q., Gao, Y.-S., & Guo, Y.-P. (2021). Gelatin methacryloyl hydrogels functionalized with endothelin-1 for angiogenesis and full-thickness wound healing. Journal of Materials Chemistry B. https://doi.org/10.1039/D1TB00449B Cite
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