Smurf1 promotes cell growth and colony formation by accelerating cell cycle and aberrant signaling pathways. In addition, the authors showed that Smurf1 ubiquitylates and degrades phosphatase and tensin homolog.
Scientists applied experimental allogeneic human neural cell therapy after injury in ex vivo spinal cord slices.
[Stem Cell Research & Therapy]
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Lin, C., Calzarossa, C., Fernandez-Zafra, T., Liu, J., Li, X., Ekblad-Nordberg, Å., Vazquez-Juarez, E., Codeluppi, S., Holmberg, L., Lindskog, M., Uhlén, P., & Åkesson, E. (2020). Human ex vivo spinal cord slice culture as a useful model of neural development, lesion, and allogeneic neural cell therapy. Stem Cell Research & Therapy, 11(1), 320. https://doi.org/10.1186/s13287-020-01771-y Cite
The therapeutic efficacy of LentiVIP was tested in a multiple low-dose STZ-induced animal model of type 1 diabetes. LentiVIP delivery into diabetic animals reduced hyperglycemia, improved glucose tolerance, and prevented weight loss.
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Erendor, F., Sahin, E. O., Sanlioglu, A. D., Balci, M. K., Griffith, T. S., & Sanlioglu, S. (2020). Lentiviral gene therapy vectors encoding VIP suppressed diabetes-related inflammation and augmented pancreatic beta-cell proliferation. Gene Therapy, 1–12. https://doi.org/10.1038/s41434-020-0183-3 Cite
Scientists demonstrated whether LINC00324 participates in non-small cell lung cancer pathogenesis through other molecular mechanism.
[Molecular and Cellular Biochemistry]
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Zhang, M., Lin, B., Liu, Y., Huang, T., Chen, M., Lian, D., Deng, S., & Zhuang, C. (2020). LINC00324 affects non-small cell lung cancer cell proliferation and invasion through regulation of the miR-139-5p/IGF1R axis. Molecular and Cellular Biochemistry. https://doi.org/10.1007/s11010-020-03819-2 Cite
Deep high-throughput sequencing approach allowed researchers to analyze the miRNA and mRNA expression profiles in HUVECS cultured under gravity, and stimulated microgravity achieved with a clinostat.
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Kasiviswanathan, D., Chinnasamy Perumal, R., Bhuvaneswari, S., Kumar, P., Sundaresan, L., Philip, M., Puthenpurackal Krishnankutty, S., & Chatterjee, S. (2020). Interactome of miRNAs and transcriptome of human umbilical cord endothelial cells exposed to short-term simulated microgravity. Npj Microgravity, 6(1), 1–10. https://doi.org/10.1038/s41526-020-00108-6 Cite
Investigators demonstrated that LRCH1 directly bound linker for activation of T cells (LAT), reduced LAT phosphorylation and interaction with GRB2, and also promoted the endocytosis of LAT.
[Proceedings of the National Academy of Sciences of the United States of America]
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Liu, C., Xu, X., Han, L., Wan, X., Zheng, L., Li, C., Liao, Z., Xiao, J., Zhong, R., Zheng, X., Wang, Q., Li, Z., Chen, H., Wei, B., & Wang, H. (2020). LRCH1 deficiency enhances LAT signalosome formation and CD8+ T cell responses against tumors and pathogens. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2000970117 Cite
Investigators demonstrated that progesterone receptor membrane component 1 played a prominent role in regulating the growth of cancer cells by altering the PI3K/AKT/mTOR and EGFR signalling mechanisms in both ER-positive and TNBC cells.
[British Journal of Cancer]
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The authors investigated a link between ubiquilin and the oncogene epidermal growth factor receptor (EGFR) in lung adenocarcinoma cells.
[Journal of Cellular Biochemistry]
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Researchers investigated up- and down-regulated genes in response to (thermo)radiotherapy in HSP70 proficient and deficient canine osteosarcoma cell line, and functional role of HSP70 in the mechanism of thermoradiosensitization.
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Scientists revealed that small KIFC1 inhibitor AZ82 suppresed the transcription and translation of KIFC1 significantly in PCa cells.
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Investigators tested if knockdown of USP10 with a USP10-targeting sdRNA reduced scarring after wounding a rabbit cornea in vivo.
[Molecular Therapy-Nucleic Acids]
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Boumil, E. F., Castro, N., Phillips, A. T., Chatterton, J. E., McCauley, S. M., Wolfson, A. D., Shmushkovich, T., Ridilla, M., & Bernstein, A. M. (2020). USP10 targeted self-deliverable siRNA to prevent scarring in the cornea. Molecular Therapy - Nucleic Acids, 0(0). https://doi.org/10.1016/j.omtn.2020.07.032 Cite
The effect of miR-3622a-3p on proliferation, apoptosis, cell cycle, migration and invasion of colorectal cancer (CRC) cells were investigated by a series of biological function assays and the results revealed that miR-3622a-3p could inhibit the malignant biological properties of CRC.
[Cell Death & Disease]
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