cell proliferation

[British Journal of Cancer] KDM6A promoted the transcription of SPARCL1 by demethylating histone H3 lysine trimethylation and consequently led to the inactivation of p65. SPARCL1 affected the metastasis of gastrointestinal stromal tumor cells in a mesenchymal-epithelial transition- and matrix-metalloproteinase-dependent manner.

[Cell Death & Disease] The authors revealed that the BC200/miR-150-5p/MYB positive feedback loop promoted the proliferation of myelodysplastic syndrome (MDS) cells and was expected to be a potential biomarker and therapeutic target in MDS.

[Cell Cycle] The vascular endothelial cells (VECs) were isolated and treated severally, and then proliferation and migration of VECs were measured.

[Experimental Eye Research] Researchers generated a diabetic retinopathy (DR) animal model using mice and a cell model in mouse retinal microvascular endothelial cells to examine the role of Trefoil factor family 1 in DR.

[Molecular Biology Reports] Scientists used a bird model to illustrate the potential roles of sclerostin (SOST) on duck myoblasts to verify the hypothesis that SOST might play functions in coordinating the development of bones and muscles.

[Cancer Science] Scientists investigated the effect of PMD-026 on YB-1/AR signaling and its antitumor effect in prostate cancer in vitro and in vivo and demonstrated an excellent antitumor effect of the novel ribosomal S6 kinase inhibitor PMD-026 and the combination effect with the antiandrogen enzalutamide in CRPC.