cell proliferation

[RNA] Scientists reported that three splicing factors, SPF45, SR140 and CHERP formed a tight physical and functionally coherent complex that regulated a variety of alternative splicing events, frequently by repressing short exons flanked by suboptimal 3' splice sites.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists assessed the effect of different adjuvants on human monocyte-derived dendritic cells and their ability to polarize innate and adaptive immune responses.

[Cancer Immunology Research] Researchers demonstrated that the anti-CD137 agonist urelumab can overcome TGFβ-mediated inhibition of human NK-cell proliferation and antitumor function.

[Cell Cycle] Researchers conducted quantitative reverse transcription PCR to find that circ_0004018 was down-regulated in hepatocellular carcinoma cells. Western blot analysis was performed to detect the protein levels of phosphatase and tensin homologue and related factors of PI3K/AKT signaling pathway.

[Tissue Engineering Part B-Reviews] The authors summarize current knowledge of hypoxia-induced changes in mesenchymal stem cells (MSCs) and discuss the application of hypoxia preconditioned MSCs as well as hypoxic secretome in different kinds of disease models.

[Acta Biomaterialia] Researchers determined that M2-Exos could augment the angiogenic activities of spinal cord microvascular endothelial cells in vitro.