cell transplantation

[Cell Reports] In cell transplantation therapy for spinal cord injury, grafted human induced pluripotent stem cell-derived neural stem/progenitor cells (hiPSC-NS/PCs) differentiate into neurons. Scientists found that chemogenetic stimulation of hiPSC-derived neural cells enhancesd cell activity and neuron-to-neuron interactions in vitro.

[Cancer Discovery] Scientists generated ex vivo drug response and multi-omics profiling data for a prospective series of 252 samples from 186 acute myeloid leukemia patients. Functional precision medicine tumor board integrated clinical, molecular and functional data for application in clinical treatment decisions.

[Journal of Clinical Oncology] Scientists reported that the risk of donor cell leukemia in allogeneic hematopoietic cell transplantation was driven by somatic myelodysplastic syndrome–associated mutations or germline predisposition in donors.

[Nature Communications] Investigators developed a cell-adhesive fiber-forming peptide that mimicked the jigsaw-shaped hydrophobic surface in the dovetail-packing motif of glycophorin A as an artificial ECM for regenerative therapy.

[Cellular & Molecular Biology Letters] Stem cells, exosomes, and biomimetic materials represent emerging technologies for osteoporosis treatment. Scientists review summarizes the latest developments in these three aspects.

[Bone Marrow Transplantation] Investigators suggested that almost 80% of acute myeloid leukemia patients could undergo salvage therapy following relapse after front-line high-dose chemotherapy/autologous hematopoietic cell transplantation.