Comparable Anti-CMV Responses of Transplant Donor and Third-Party CMV-Specific T Cells for Treatment of CMV Infection after Allogeneic Stem Cell Transplantation

The in vivo recovery of cytomegalovirus (CMV)-specific immunity after CMV-cytotoxic T lymphocytes (CTL) infusion was comparable in two groups. A detailed analysis of the source of recovered CMV-CTLs showed the proliferation and expansion of graft-derived endogenous CMV-CTLs in both groups.
[Cellular & Molecular Immunology]
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Naive T Cell Depletion to Prevent Chronic Graft-Versus-Host Disease

138 patients with acute leukemia received Naive T cell-depleted peripheral blood stem-cell from HLA-matched related or unrelated donors following conditioning with high- or intermediate-dose total-body irradiation and chemotherapy.
[Journal of Clinical Oncology]
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Research Progress of the Application of Mesenchymal Stem Cells in Chronic Inflammatory Systemic Diseases

The authors describe the research progress and clinical application of MSCs in chronic inflammatory systemic diseases and look for influencing factors and biomarkers that can predict the outcome of patient with mesenchymal stem cell transplantation.
[Stem Cell Research & Therapy]
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Genome-Wide Association Study on 13,167 Individuals Identifies Regulators of Blood CD34+ Cell Levels

Scientists reported the first large-scale genome-wide association study on blood CD34+ cell levels. Across 13,167 individuals, they identified 9 significant and 2 suggestive associations, accounted for by 8 loci.
[Blood]
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Hypomethylating Agent-Based Combination Therapies to Treat Post-Hematopoietic Stem Cell Transplant Relapse of Acute Myeloid Leukemia

The authors report on mechanism of action, safety, and efficacy data on combination strategies based on hypomethylating agents in the setting of post-allogeneic stem cell transplant relapse.
[Frontiers in Oncology]
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Use of CAR T Cell for Acute Lymphoblastic Leukemia (ALL) Treatment: A Review Study

Scientists discuss different generations, challenges, and clinical studies related to chimeric antigen receptor (CAR) T cells for ALL treatment.
[Cancer Gene Therapy]
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Researchers Awarded Grant to Study New Method of Islet Transplantation

Weill Cornell Medicine researchers have received a two-year $500,000 grant from JDRF to evaluate an innovative approach to islet cell transplantation, an experimental treatment for difficult-to-control type 1 diabetes.
[Weill Cornell Medicine]
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HLA 1–3 Antigen-Mismatched Related Peripheral Blood Stem Cells Transplantation Using Low-Dose Antithymocyte Globulin versus Unrelated Cord Blood Transplantation

Researchers evaluated 7861 patients with hematologic malignancies who received either a cord blood transplantr without anti-thymocyte globulin (ATG) or an HLA 1-3 antigen–mismatched related donor peripheral blood stem-cell transplantation using low-dose ATG.
[American Journal of Hematology]
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Hematopoietic Stem Cell Gene Editing and Expansion: State-of-the-Art Technologies and Recent Applications

Scientists present a summary and discussion of the implications of new approaches to improve hematopoietic stem cell transplantation-based therapy.
[Experimental Hematology]
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Monitoring of Post-Transplant MLL-PTD as Minimal Residual Disease Can Predict Relapse after Allogeneic HSCT in Patients with Acute Myeloid Leukemia and Myelodysplastic Syndrome

Investigators retrospectively collected the clinical data of 48 patients with mixed-lineage leukemia (MLL)-partial tandem duplications (PTD) acute myeloid leukemia or myelodysplastic syndrome with excess blasts who underwent allogeneic hematopoietic stem cell transplantation (HSCT) in Peking University People’s Hospital.
[BMC Cancer]
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Post-Hematopoietic Stem Cell Transplantation Immune-Mediated Anemia: A Literature Review and Novel Therapeutics

Scientists summarize the literature on post-hematopoietic stem cell transplantation immune-mediated anemia with a focus on ABO and non-ABO blood group incompatibility, described the underlying mechanism of anemia, and outlined preventive and treatment approaches.
[Blood Advances]
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