chondrocytes

[NPJ Regenerative Medicine] Scientists reported that the incorporation of gelatin microparticles coloaded with transforming growth factor beta 3 and matrilin 3 promoted chondrogenic differentiation of adipose-derived MSC spheroids while preventing hypertrophy and terminal differentiation of cells.

[Evidence-Based Complementary and Alternative Medicine] After warm acupuncture combined with bone-marrow MSCs, the Modified Lequesne MG knee joint assessment scale was used to evaluate the degree of knee joint behavior, the Taiping Peng method generally observed the histomorphology changes of knee osteoarthritis rabbit cartilage, and hematoxylin-eosin staining, safranin O green staining, and toluidine blue staining were conducted to evaluate the extent of cartilage tissue pathology.

[Tissue Engineering Part A] Scientists prepared cartilage from human iPSCs (hiPS-Cart) in a scaffoldless manner and implanted hiPS-Cart into 3.5 mm large defects created in the femurs of immunodeficient mice to examine the repair capacity.

[Journal of Cellular and Molecular Medicine] Researchers compared the therapeutic potential of induced pluripotent stem cells differentiation into MSCs generated from urinary epithelial cells with the available umbilical cord MSCs.

[Acta Biomaterialia] The authors focused on the collagen content in the cartilage cell microenvironment of healthy and osteoarthritic cartilage.

[Nature Biomedical Engineering] Scientists reported a protocol that leveraged PRRX1–tdTomato reporter human PSCs for the selective induction of expandable and ontogenetically defined PRRX1+ limb-bud-like mesenchymal cells under defined xeno-free conditions.