chronic inflammation

[iScience] Researchers addressed the contribution of posttranscriptional regulation, by the RNA-binding protein CPEB4, to intestinal immune homeostasis and its role in inflammatory bowel diseases and CRC development.

[Cellular & Molecular Immunology] The authors highlight the interaction of neutrophils with other cells in the context of chronic inflammation, the contribution of neutrophils to selected chronic inflammatory diseases, and possible future therapeutic strategies.

[Trends in Immunology] The authors detail the novel cellular sensors that are dependent on K63 ubiquitination for their function in the immune signaling network.

[Hepatology] Scientists review the specific functions of several T cell populations involved in NAFLD and NAFLD-driven HCC.

[Blood Advances] The authors defined the prevalence and variation of clonal hematopoiesis of indetermined potential (CHIP) over time and assessed the influence on clinical inflammation syndromes, cytopenia and outcome.

[Science] Investigators discuss how tertiary lymphoid structures (TLSs) are detected and defined, the mechanism(s) of formation in cancer, and the potential of targeting TLSs for therapeutic benefit.