chronic kidney disease

[International Immunopharmacology] Scientists examined the effect of interferon regulatory factor 4 (IRF-4) deficiency on inflammation and kidney fibrosis in an acute kidney injury-chronic kidney disease transition model induced by folic acid injury.

[Cell Reports] The authors used an integrated epigenome and transcriptome analysis of mouse non-alcoholic fatty liver disease (NAFLD) hepatocytes and identified alterations in glyoxylate metabolism, a pathway relevant in kidney damage via oxalate release—a harmful waste product and kidney stone-promoting factor.

[Nature Reviews Nephrology] In self-limiting inflammation, the evolving inflammatory response is coupled to distinct processes that promote the resolution of inflammation and restore homeostasis.

[Bayer, Inc.] Bayer announced that the US FDA has approved finerenone, the first non-steroidal, selective mineralocorticoid receptor (MR) antagonist, under the brand name Kerendia®.

[University of California, Los Angeles] Dr. Elizabeta Nemeth, professor of medicine and director of the Center for Iron Disorders at the David Geffen School of Medicine at UCLA, has been awarded the 2021 William Dameshek Prize by the American Society of Hematology for her contributions to the field of hematology.

[Scientific Reports] Investigators reported the differentiation and characterization of iPSC lines into proximal tubular-like cells.