colorectal cancer

[Signal Transduction and Targeted Therapy] The authors focus on an overview of the recent advances in understanding the molecular basis of colorectal liver metastasis (CRLM) with a special emphasis on tumor microenvironment and promise of newer targeted therapies for CRLM, further improving the prognosis of CRLM patients.

[Mainz Biomed N.V.] Mainz Biomed N.V. announced that, together with its German partner laboratories, it will join a collective of physicians, healthcare professionals, laboratories and healthcare organizations in a national campaign to raise awareness for colorectal cancer screening.

[European Journal of Histochemistry] Researchers showed that the level of miR-19a was significantly higher in clinical CRC tissue samples than in paracancerous tissue samples, and significantly higher in CRC cells lines HT29, SW480, and CaCO2 than in the normal human colon mucosal epithelial cell line NCM460.

[JCI Insight] While azoxymethane delivery in vivo under non-adenoma-forming conditions yielded phenotypically normal mucosa and organoids derived thereof, niche injury ex vivo by progressive dextran sulfate sodium dose escalation facilitated outgrowth of Wnt-independent dysplastic organoids.

[Molecular Therapy] The authors extracted and identified primary MSCs and verified the promoting effects of tumor-associated MSCs on colorectal cancer proliferation and metastasis in vivo and in vitro.

[Journal of Experimental & Clinical Cancer Research] Investigators generated organoids from circulating tumor cells isolated from an orthotopic colorectal cancer xenograft model.