Modeling Coronavirus Spike Protein Dynamics: Implications for Immunogenicity and Immune Escape

Investigators developed computational models for a large subset of S proteins associated with SARS-CoV-2, implemented through coarse-grained elastic network models and normal mode analysis.
[Biophysical Journal]
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An Aluminum Hydroxide:CpG Adjuvant Enhances Protection Elicited by a SARS-CoV-2 Receptor-Binding Domain Vaccine in Aged Mice

Investigators compared pattern recognition receptor agonists alone or formulated with aluminum hydroxide and benchmarked them against AS01B and AS03-like emulsion-based adjuvants for their potential to enhance receptor-binding domain immunogenicity in young and aged mice.
[Science Translational Medicine]
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Cross-Validation of SARS-CoV-2 Responses in Kidney Organoids and Clinical Populations

Scientists combined SARS-CoV-2 variants with genome edited kidney organoids and clinical data to investigate tropism, mechanism, and therapeutics.
[JCI Insight]
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Organ-Specific Genome Diversity of Replication-Competent SARS-CoV-2

Scientists reported a detailed virological analysis of 13 postmortem COVID-19 cases that provided proof of viremia and presence of replication-competent SARS-CoV-2 in extrapulmonary organs of immunocompromised patients, including heart, kidney, liver, and spleen.
[Nature Communications]
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SARS-CoV-2 Inhibits Induction of the MHC Class I Pathway by Targeting the STAT1-IRF1-NLRC5 Axis

Analysis of the gene expression profile from COVID-19 patients as well as SARS-CoV-2 infected epithelial cell lines revealed that the induction of the MHC class I pathway was inhibited by SARS-CoV-2 infection.
[Nature Communications]
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Mesenchymal Stromal Cell-Derived Extracellular Vesicles Reduce Lung Inflammation and Damage in Nonclinical Acute Lung Injury: Implications for COVID-19

Researchers identified a role for MSC-extracellular vesicles in immune modulation and cellular salvage in a model of SARS-CoV-2 induced acute lung injury using pulmonary epithelial cells and exposure to cytokines or the SARS-CoV-2 receptor binding domain.
[PLoS One]
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SARS-CoV-2 Infection and Replication in Human Gastric Organoids

Scientists generated gastric organoids from fetal, pediatric, and adult biopsies as in vitro models of SARS-CoV-2 infection.
[Nature Communications]
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Crosstalk between the Renin–Angiotensin, Complement and Kallikrein–Kinin Systems in Inflammation

The authors describe the interactive roles of the renin–angiotensin system, the complement system, and the closely linked kallikrein–kinin and contact systems in cell biological functions such as vascular tone and leakage, inflammation, chemotaxis, thrombosis and cell proliferation.
[Nature Reviews Immunology]
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Primary Endpoint Met in COMET-TAIL Phase III Trial Evaluating Intramuscular Administration of Sotrovimab for Early Treatment of COVID-19

GlaxoSmithKline plc and Vir Biotechnology, Inc. announced headline data from the randomised, multi-centre, open-label COMET-TAIL Phase III trial, which achieved its primary endpoint, demonstrating intramuscular administration of sotrovimab was non-inferior to intravenous administration for the early treatment of mild-to-moderate COVID-19 in high-risk, non-hospitalised adults and adolescents.
[GlaxoSmithKline plc]
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Common Cardiac Medications Potently Inhibit ACE2 Binding to the SARS-CoV-2 Spike, and Block Virus Penetration and Infectivity in Human Lung Cells

Researchers found that ouabain, digitoxin and digoxin blocked penetration by SARS-CoV-2 Spike-pseudotyped virus into human lung cells, and infectivity by native SARS-CoV-2.
[Scientific Reports]
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CN Bio and iiCON Announce COVID-19 Research Collaboration

CN Bio announced a research collaboration with the Infection Innovation Consortium (iiCON), a global collaborative infectious disease R&D programme, to validate the next generation of COVID-19 research tools.
[CN Bio]
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