Interleukin-10 and Small Molecule SHIP1 Allosteric Regulators Trigger Anti-Inflammatory Effects Through SHIP1/STAT3 Complexes

Scientists report that IL10, but not IL6 signaling, induced formation of a complex between STAT3 and the inositol polyphosphate-5-phosphatase SHIP1 in macrophages.
[iScience]
Chamberlain, T. C., Cheung, S. T., Yoon, J. S. J., Ming-Lum, A., Gardill, B. R., Shakibakho, S., Dzananovic, E., Ban, F., Samiea, A., Jawanda, K., Priatel, J., Krystal, G., Ong, C. J., Cherkasov, A., Andersen, R. J., McKenna, S. A., Petegem, F. V., & Mui, A. L.-F. (2020). Interleukin-10 and Small Molecule SHIP1 Allosteric Regulators Trigger Anti-Inflammatory Effects Through SHIP1/STAT3 Complexes. IScience, 0(0). https://doi.org/10.1016/j.isci.2020.101433 Cite
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Anti-SARS-CoV-2 Activities In Vitro of Shuanghuanglian Preparations and Bioactive Ingredients

The authors showed that either the oral liquid of Shuanghuanglian, the lyophilized powder of Shuanghuanglian for injection or their bioactive components dose-dependently inhibited SARS-CoV-2 3CLpro as well as the replication of SARS-CoV-2 in Vero E6 cells.
[Acta Pharmacologica Sinica]
Su, H., Yao, S., Zhao, W., Li, M., Liu, J., Shang, W., Xie, H., Ke, C., Hu, H., Gao, M., Yu, K., Liu, H., Shen, J., Tang, W., Zhang, L., Xiao, G., Ni, L., Wang, D., Zuo, J., … Xu, Y. (2020). Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients. Acta Pharmacologica Sinica, 1–11. https://doi.org/10.1038/s41401-020-0483-6 Cite
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