crystallography

[Science Advances] Combining crystallography, glycobiology, and functional B cell assays allowed researchers to dissect key characteristics of variable domain glycans on human B cell biology.

[Science] Investigators screened a library of 1900 clinically safe drugs against OC43, a human beta coronavirus that causes the common cold, and evaluated the top hits against SARS-CoV-2.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists generated a series of deuterated variants of a 3CLpro inhibitor, GC376, and evaluated the antiviral effect against SARS-CoV-2.

[Cell] Scientists identified 377 human monoclonal antibodies recognizing the virus spike, and focused mainly on 80 that bind the receptor binding domain.

[Journal of Medicinal Chemistry] The authors optimized a small series of 4-acyl pyrroles, which they further analyzed by ITC, X-ray crystallography, selectivity studies, the NCI60 cell-panel, and GI50 determinations for several cancer cell lines.

[Nature Reviews Microbiology] Scientists discuss recent insights into herpesvirus entry by analysing the structures of entry glycoproteins, including the diverse receptor-binding glycoproteins, EBV glycoprotein 42 and HCMV gH–gL–gO trimer and gH–gL–UL128–UL130–UL131A pentamer.