The Antigenic Anatomy of SARS-CoV-2 Receptor Binding Domain

Scientists identified 377 human monoclonal antibodies recognizing the virus spike, and focused mainly on 80 that bind the receptor binding domain.
[Cell]
Dejnirattisai, W., Zhou, D., Ginn, H. M., Duyvesteyn, H. M. E., Supasa, P., Case, J. B., Zhao, Y., Walter, T. S., Mentzer, A. J., Liu, C., Wang, B., Paesen, G. C., Slon-Campos, J., López-Camacho, C., Kafai, N. M., Bailey, A. L., Chen, R. E., Ying, B., Thompson, C., … Screaton, G. R. (2021). The antigenic anatomy of SARS-CoV-2 receptor binding domain. Cell, 0(0). https://doi.org/10.1016/j.cell.2021.02.032 Cite
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4-Acyl Pyrroles as Dual BET-BRD7/9 Bromodomain Inhibitors Address BETi Insensitive Human Cancer Cell Lines

The authors optimized a small series of 4-acyl pyrroles, which they further analyzed by ITC, X-ray crystallography, selectivity studies, the NCI60 cell-panel, and GI50 determinations for several cancer cell lines.
[Journal of Medicinal Chemistry]
Hügle, M., Regenass, P., Warstat, R., Hau, M., Schmidtkunz, K., Lucas, X., Wohlwend, D., Einsle, O., Jung, M., Breit, B., & Günther, S. (2020). 4-Acyl Pyrroles as Dual BET-BRD7/9 Bromodomain Inhibitors Address BETi Insensitive Human Cancer Cell Lines. Journal of Medicinal Chemistry. https://doi.org/10.1021/acs.jmedchem.0c00478 Cite
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The Structural Basis of Herpesvirus Entry

Scientists discuss recent insights into herpesvirus entry by analysing the structures of entry glycoproteins, including the diverse receptor-binding glycoproteins, EBV glycoprotein 42 and HCMV gH–gL–gO trimer and gH–gL–UL128–UL130–UL131A pentamer.
[Nature Reviews Microbiology]
Connolly, S. A., Jardetzky, T. S., & Longnecker, R. (2020). The structural basis of herpesvirus entry. Nature Reviews Microbiology, 1–12. https://doi.org/10.1038/s41579-020-00448-w Cite
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Structural Insight Into the Staphylococcus Aureus ATP-Driven Exporter of Virulent Peptide Toxins

Scientists demonstrated that the minimal Pmt unit necessary for PSM export is PmtCD and provided its first atomic characterization by single-particle cryo-EM and x-ray crystallography. They have captured the transporter in the ATP-bound state at near atomic resolution, revealing a type II ABC exporter fold, with an additional cytosolic domain.
[Science Advances]
Structural insight into the Staphylococcus aureus ATP-driven exporter of virulent peptide toxins | Science Advances. (n.d.). Retrieved October 5, 2020, from https://advances.sciencemag.org/content/6/40/eabb8219 Cite
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Interleukin-10 and Small Molecule SHIP1 Allosteric Regulators Trigger Anti-Inflammatory Effects Through SHIP1/STAT3 Complexes

Scientists report that IL10, but not IL6 signaling, induced formation of a complex between STAT3 and the inositol polyphosphate-5-phosphatase SHIP1 in macrophages.
[iScience]
Chamberlain, T. C., Cheung, S. T., Yoon, J. S. J., Ming-Lum, A., Gardill, B. R., Shakibakho, S., Dzananovic, E., Ban, F., Samiea, A., Jawanda, K., Priatel, J., Krystal, G., Ong, C. J., Cherkasov, A., Andersen, R. J., McKenna, S. A., Petegem, F. V., & Mui, A. L.-F. (2020). Interleukin-10 and Small Molecule SHIP1 Allosteric Regulators Trigger Anti-Inflammatory Effects Through SHIP1/STAT3 Complexes. IScience, 0(0). https://doi.org/10.1016/j.isci.2020.101433 Cite
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Anti-SARS-CoV-2 Activities In Vitro of Shuanghuanglian Preparations and Bioactive Ingredients

The authors showed that either the oral liquid of Shuanghuanglian, the lyophilized powder of Shuanghuanglian for injection or their bioactive components dose-dependently inhibited SARS-CoV-2 3CLpro as well as the replication of SARS-CoV-2 in Vero E6 cells.
[Acta Pharmacologica Sinica]
Su, H., Yao, S., Zhao, W., Li, M., Liu, J., Shang, W., Xie, H., Ke, C., Hu, H., Gao, M., Yu, K., Liu, H., Shen, J., Tang, W., Zhang, L., Xiao, G., Ni, L., Wang, D., Zuo, J., … Xu, Y. (2020). Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients. Acta Pharmacologica Sinica, 1–11. https://doi.org/10.1038/s41401-020-0483-6 Cite
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