Investigators investigated the interplay and networking pathways occurring between TGFβ family ligands in regulating stemness in triple negative breast cancer (TNBC). They found that TGFβ stimulation of TNBCs resulted in enhanced tumorsphere formation efficiency and an increased proportion of the highly tumorigenic CD44high/CD24low cancer stem cell population.
[Oncogenesis]
Yan, G., Dai, M., Zhang, C., Poulet, S., Moamer, A., Wang, N., Boudreault, J., Ali, S., & Lebrun, J.-J. (2021). TGFβ/cyclin D1/Smad-mediated inhibition of BMP4 promotes breast cancer stem cell self-renewal activity. Oncogenesis, 10(3), 1–14. https://doi.org/10.1038/s41389-021-00310-5 Cite
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