YWHAE-NUTM2 Oncoprotein Regulates Proliferation and Cyclin D1 via RAF/MAPK and Hippo Pathways

The authors showed YWHAE-NUTM2 complexes with both BRAF/RAF1 and YAP/TAZ in high-grade endometrial stromal sarcoma (HG-ESS). These interactions were functionally relevant because YWHAE-NUTM2 knockdown in HG-ESS and other models inhibits RAF/MEK/MAPK phosphorylation, cyclin D1 expression, and cell proliferation.
[Oncogenesis]
Ou, W.-B., Lundberg, M. Z., Zhu, S., Bahri, N., Kyriazoglou, A., Xu, L., Chen, T., Mariño-Enriquez, A., & Fletcher, J. A. (2021). YWHAE-NUTM2 oncoprotein regulates proliferation and cyclin D1 via RAF/MAPK and Hippo pathways. Oncogenesis, 10(5), 1–9. https://doi.org/10.1038/s41389-021-00327-w Cite
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Anti-cancer & Anti-metastasis Properties of Bioorganic-Capped Silver Nanoparticles Fabricated from Juniperus chinensis Extract against Lung Cancer Cells

The authors elucidated the cellular and molecular mechanisms of nanoparticles for anti-proliferative and apoptotic effects on human lung cancer cells and compared them with commercial drug cisplatin.
[Amb Express]
Noorbazargan, H., Amintehrani, S., Dolatabadi, A., Mashayekhi, A., Khayam, N., Moulavi, P., Naghizadeh, M., Mirzaie, A., Mirzaei rad, F., & Kavousi, M. (2021). Anti-cancer & anti-metastasis properties of bioorganic-capped silver nanoparticles fabricated from Juniperus chinensis extract against lung cancer cells. AMB Express, 11(1), 61. https://doi.org/10.1186/s13568-021-01216-6 Cite
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Inhibition of eEF2K Synergizes with Glutaminase Inhibitors or 4EBP1 Depletion to Suppress Growth of Triple-Negative Breast Cancer Cells

Researchers showed that genetic or pharmacological inhibition of eukaryotic elongation factor-2 kinase (eEF2K) cooperated with glutamine starvation, and synergized with glutaminase inhibitors to suppress growth of diverse TNBC cell lines.
[Scientific Reports]
Ju, Y., Ben-David, Y., Rotin, D., & Zacksenhaus, E. (2021). Inhibition of eEF2K synergizes with glutaminase inhibitors or 4EBP1 depletion to suppress growth of triple-negative breast cancer cells. Scientific Reports, 11(1), 9181. https://doi.org/10.1038/s41598-021-88816-1 Cite
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Tumor-Derived Exosomal circPSMA1 Facilitates the Tumorigenesis, Metastasis, and Migration in Triple-Negative Breast Cancer (TNBC) through miR-637/Akt1/β-Catenin (Cyclin D1) Axis

Investigators explored the novel mechanisms by which exosome-contained circRNAs promoted tumor development and metastasis in TNBC.
[Cell Death & Disease]
Yang, S., Wang, D., Zhong, S., Chen, W., Wang, F., Zhang, J., Xu, W., Xu, D., Zhang, Q., Li, J., Zhang, H., Hou, J., Mao, L., & Tang, J. (2021). Tumor-derived exosomal circPSMA1 facilitates the tumorigenesis, metastasis, and migration in triple-negative breast cancer (TNBC) through miR-637/Akt1/β-catenin (cyclin D1) axis. Cell Death & Disease, 12(5), 1–20. https://doi.org/10.1038/s41419-021-03680-1 Cite
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PDGF-Mediated Activation of CREB in Vascular Smooth Muscle Cells Alters Cell Cycling Via Rb, FoxO1 and p27kip1

Researchers show CREB phosphorylation was required for smooth muscle cell proliferation in response to platelet-derived growth factor (PDGF). This phenotypic change required CBP and was mediated by Cyclin D1 and p27kip as a result of changes in FoxO1 activity.
[Experimental Cell Research]
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FAK in the Nucleus Prevents VSMC Proliferation by Promoting p27 and p21 Expression via Skp2 Degradation

Both pharmacological focal adhesion kinase (FAK) and genetic FAK inhibition reduced S-phase kinase-associated protein 2 (Skp2) expression in Vascular smooth muscle cells (VSMCs) upon injury, which significantly reduced intimal hyperplasia through elevated expression of p27 and p21.
[Cardiovascular Research]
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PRDM4 Inhibits Cell Proliferation and Tumorigenesis by Inactivating the PI3K/AKT Signaling Pathway through Targeting of PTEN in Cervical Carcinoma

Both immunohistochemistry and Western blot assays demonstrated that the expression of PR domain zinc finger protein 4 (PRDM4) in cervical cancer tissues was much lower than that in the normal cervix.
[Oncogene]
Yang, W.-T., Chen, M., Xu, R., & Zheng, P.-S. (2021). PRDM4 inhibits cell proliferation and tumorigenesis by inactivating the PI3K/AKT signaling pathway through targeting of PTEN in cervical carcinoma. Oncogene, 1–13. https://doi.org/10.1038/s41388-021-01765-x Cite
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MCPIP1-Mediated NFIC Alternative Splicing Inhibits Proliferation of Triple-Negative Breast Cancer via Cyclin D1-RB-E2F1 Axis

Investigators showed that monocyte chemotactic protein induced protein 1 (MCPIP1) was downregulated in 80 TNBC tissues and five TNBC cell lines compared to adjacent paracancerous tissues and one human immortalized breast epithelial cell line, while its high expression levels were associated with increased overall survival in TNBC patients.
[Cell Death & Disease]
Chen, F., Wang, Q., Yu, X., Yang, N., Wang, Y., Zeng, Y., Zheng, Z., Zhou, F., & Zhou, Y. (2021). MCPIP1-mediated NFIC alternative splicing inhibits proliferation of triple-negative breast cancer via cyclin D1-Rb-E2F1 axis. Cell Death & Disease, 12(4), 1–16. https://doi.org/10.1038/s41419-021-03661-4 Cite
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The Adipose-Derived Mesenchymal Stem Cell Secretome Promotes Hepatic Regeneration in Miniature Pigs after Liver Ischemia-Reperfusion Combined with Partial Resection

24 miniature pigs were subjected to laparoscopic liver ischemia-reperfusion combined with partial hepatectomy and divided into the following four groups: the saline group, the DMEM group, the adipose-derived MSC (ASC) group and the ASC-secretome group.
[Stem Cell Research & Therapy]
Jiao, Z., Ma, Y., Zhang, Q., Wang, Y., Liu, T., Liu, X., Piao, C., Liu, B., & Wang, H. (2021). The adipose-derived mesenchymal stem cell secretome promotes hepatic regeneration in miniature pigs after liver ischaemia-reperfusion combined with partial resection. Stem Cell Research & Therapy, 12(1), 218. https://doi.org/10.1186/s13287-021-02284-y Cite
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Dysregulation of miR-23b-5p Promotes Cell Proliferation via Targeting FOXM1 in Hepatocellular Carcinoma

Gain- or loss-of-function assays demonstrated that miR-23b-5p induced G0/G1 cell cycle arrest and inhibited cell proliferation both in vitro and in vivo. qRT-PCR, western blot and luciferase assays verified that Mammalian transcription factor Forkhead Box M1 (FOXM1), upregulated in hepatocellular carcinoma specimens, was negatively correlated with miR-23b-5p expression and acted as a direct downstream target of miR-23b-5p.
[Cell Death Discovery]
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Gli2-Regulated Activation of Hepatic Stellate Cells and Liver Fibrosis by TGF-β Signaling

Scientists investigated the effect of Gli2 on liver fibrogenesis and its possible mechanism using conditional knockout Gli2 mice and hepatic stellate cell models.
[American Journal of Physiology-Gastrointestinal and Liver Physiology]
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