TGFβ/Cyclin D1/Smad-Mediated Inhibition of BMP4 Promotes Breast Cancer Stem Cell Self-Renewal Activity

Investigators investigated the interplay and networking pathways occurring between TGFβ family ligands in regulating stemness in triple negative breast cancer (TNBC). They found that TGFβ stimulation of TNBCs resulted in enhanced tumorsphere formation efficiency and an increased proportion of the highly tumorigenic CD44high/CD24low cancer stem cell population.
[Oncogenesis]
Yan, G., Dai, M., Zhang, C., Poulet, S., Moamer, A., Wang, N., Boudreault, J., Ali, S., & Lebrun, J.-J. (2021). TGFβ/cyclin D1/Smad-mediated inhibition of BMP4 promotes breast cancer stem cell self-renewal activity. Oncogenesis, 10(3), 1–14. https://doi.org/10.1038/s41389-021-00310-5 Cite
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A Synthetic mRNA Cell Reprogramming Method Using CYCLIN D1 Promotes DNA Repair Generating Improved Genetically Stable Human Induced Pluripotent Stem Cells

Investigators demonstrated that CYCLIN D1 made induced pluripotent stem cells have lower multitelomeric signal, reduced double‐strand DNA breaks, correct nuclear localization of RAD51 protein expression, and reduced SNP changes per chromosome, compared with the classical reprogramming method using C‐MYC.
[Stem Cells]
Alvarez‐Palomo, A. B., Requena‐Osete, J., Delgado‐Morales, R., Moreno‐Manzano, V., Grau‐Bove, C., Tejera, A. M., Otero, M. J., Barrot, C., Santos‐Barriopedro, I., Vaquero, A., Mezquita‐Pla, J., Moran, S., Naya, C. H., Garcia‐Martínez, I., Pérez, F. V., Blasco, M. A., Esteller, M., & Edel, M. J. (n.d.). A synthetic mRNA cell reprogramming method using CYCLIN D1 promotes DNA repair generating improved genetically stable human induced pluripotent stem cells. STEM CELLS, n/a(n/a). https://doi.org/https://doi.org/10.1002/stem.3358 Cite
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ZRSR2 Overexpression Is a Frequent and Early Event in Castration-Resistant Prostate Cancer Development

Scientists identified potential early driver genes responsible for castration-resistant prostate cancer development.
[Prostate Cancer and Prostatic Diseases]
He, H., Hao, J., Dong, X., Wang, Y., Xue, H., Qu, S., Choi, S. Y. C., Ci, X., Wang, Y., Wu, R., Shi, M., Zhao, X., Collins, C., Lin, D., & Wang, Y. (2021). ZRSR2 overexpression is a frequent and early event in castration-resistant prostate cancer development. Prostate Cancer and Prostatic Diseases, 1–11. https://doi.org/10.1038/s41391-021-00322-7 Cite
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Deferasirox Induces Cyclin D1 Degradation and Apoptosis in Mantle Cell Lymphoma in a Reactive Oxygen Species- and GSK3β-Dependent Mechanism

Scientists demonstrated that the clinically approved iron chelator deferasirox exerts an anti‐tumoral effect in mantle cell lymphoma cell lines and patient cells.
[British Journal of Haematology]
Samara, A., Shapira, S., Lubin, I., Shpilberg, O., Avigad, S., Granot, G., & Raanani, P. (n.d.). Deferasirox induces cyclin D1 degradation and apoptosis in mantle cell lymphoma in a reactive oxygen species- and GSK3β-dependent mechanism. British Journal of Haematology, n/a(n/a). https://doi.org/https://doi.org/10.1111/bjh.17284 Cite
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Zeb1 Serves An Oncogenic Role In The Tumorigenesis Of HCC By Promoting Cell Proliferation, Migration, And Inhibiting Apoptosis Via Wnt/β-catenin Signaling Pathway

Scientists demonstrated that the expression level of ZEB1 was significantly elevated both in liver tissues of hepatocellular carcinoma (HCC) patients and cell lines. Moreover, ZEB1 could promote the proliferation, migration, and invasion of HCC cells.
[Acta Pharmacologica Sinica]
Li, L., Yang, J., Rong, F., Luo, Z., Hu, S., Fang, H., Wu, Y., Yao, R., Kong, W., Feng, X., Chen, B., Li, J., & Xu, T. (2021). ZEB1 serves an oncogenic role in the tumourigenesis of HCC by promoting cell proliferation, migration, and inhibiting apoptosis via Wnt/β-catenin signaling pathway. Acta Pharmacologica Sinica, 1–14. https://doi.org/10.1038/s41401-020-00575-3 Cite
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MicroRNA-331 Inhibits Isoproterenol-Induced Expression of Profibrotic Genes in Cardiac Myofibroblasts via the TGFβ/smad3 Signaling Pathway

Scientists provided evidence to prove that the fibrosis process could be regulated by miR-331 through targeting TGFβ signaling.
[Scientific Reports]
Yousefi, F., Soltani, B. M., & Rabbani, S. (2021). MicroRNA‑331 inhibits isoproterenol‑induced expression of profibrotic genes in cardiac myofibroblasts via the TGFβ/smad3 signaling pathway. Scientific Reports, 11(1), 2548. https://doi.org/10.1038/s41598-021-82226-z Cite
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A Fusion of CD63–BCAR4 Identified in Lung Adenocarcinoma Promotes Tumorigenicity and Metastasis

Based on the analysis of RNA-sequencing data, investigators identified a fusion transcript of CD63–breast cancer anti-oestrogen-resistance 4 (BCAR4) in a Korean patient with lung adenocarcinoma who did not harbour any known activating mutations in EGFR and KRAS genes. To investigate the oncogenic effect of CD63–BCAR4, in vitro and in vivo animal experiments were performed.
[British Journal of Cancer]
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PDGF Mediates Pulmonary Arterial Smooth Muscle Cell Proliferation and Migration by Regulating NFATc2

Researchers investigated whether platelet‑derived growth factor (PDGF) affects the proliferation and migration of pulmonary arterial smooth muscle cells by regulating nuclear factor of activated T cell (NFAT), and to study the pathogenesis of pulmonary arterial hypertension.
[Molecular Medicine Reports]
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8-Epi-Xanthatin Induces the Apoptosis of DU145 Prostate Carcinoma Cells through Signal Transducer and Activator of Transcription 3 Inhibition and Reactive Oxygen Species Generation

The authors found STAT3 inhibitors from natural sources and found that Xanthium fruit extracts decreased phosphorylation of STAT3‐Y705. 8‐Epi‐xanthatin (EXT) was isolated from the extracts. When DU145 prostate cancer cells were treated with EXT, p‐STAT3‐Y705 was decreased with an IC50 of 3.2μM.
[Phytotherapy Research]
Lee, Y.-J., Choi, J., Yoon, Y. J., Sim, Y., Ryu, H. W., Oh, S.-R., Kim, D.-Y., Hwang, J., Chi, S.-W., Han, D. C., & Kwon, B.-M. (n.d.). 8-Epi-xanthatin induces the apoptosis of DU145 prostate carcinoma cells through signal transducer and activator of transcription 3 inhibition and reactive oxygen species generation. Phytotherapy Research, n/a(n/a). https://doi.org/https://doi.org/10.1002/ptr.6918 Cite
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Coffee Decoction Enhances Tamoxifen Proapoptotic Activity on MCF-7 Cells

Scientists clarified how coffee decoction exerts anti-cancer effects in cooperation with tamoxifen using the estrogen receptor α-positive breast cancer cell line, MCF-7.
[Scientific Reports]
Funakoshi-Tago, M., Tago, K., Li, C., Hokimoto, S., & Tamura, H. (2020). Coffee decoction enhances tamoxifen proapoptotic activity on MCF-7 cells. Scientific Reports, 10(1), 19588. https://doi.org/10.1038/s41598-020-76445-z Cite
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LncRNA DILA1 Inhibits Cyclin D1 Degradation and Contributes to Tamoxifen Resistance in Breast Cancer

Scientists identified a lncRNA, DILA1, which interacts with Cyclin D1 and is overexpressed in tamoxifen-resistant breast cancer cells.
[Nature Communications]
LncRNA DILA1 inhibits Cyclin D1 degradation and contributes to tamoxifen resistance in breast cancer | Nature Communications. (n.d.). Retrieved November 2, 2020, from https://www.nature.com/articles/s41467-020-19349-w Cite
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