dendritic cells

[Scientific Reports] To evaluate the activation of Vγ9Vδ2 T cells by Lm-infected human monocyte-derived dendritic cells the authors engineered Lm strains that lacked components of the 2-C-methyl-D-erythritol 4- phosphate pathway.

[Proceedings of the National Academy of Sciences of the United States of America] In vitro studies demonstrated that IFP35 and NMI were released by multiple cells. IFP35 and NMI subsequently triggered nuclear factor kappa B–dependent activation of microglia via the TLR4 pathway.

[Advanced Science] Transcriptomic analysis showed that IFN-γ and IFN-α signaling was downregulated in IRF8-deficient HSCs, while their response to proinflammatory cytokines was unchanged ex vivo.

[Scientific Reports] Scientists investigated the cellular response of different antigen presenting cells to the prototypical immunogenic heat shock protein, gp96, in the context of Th1 immunity.

[Nature Communications] Researchers showed that FcγR-mediated endocytosis of antibody-antigen complexes or an anti-FcγRIIIB-antigen conjugate converted neutrophils into neutrophil-derived cells with properties of dendritic cells (DCs) that activate T cells to levels observed with classical DCs.

[Nature Communications] Lesional skin of non-responders contains higher numbers of dermal dendritic cells expressing the maturation marker CD83 and producing IL-23, and increased numbers of IL-17+ T cells.