dermal cells

[Experimental Dermatology] The authors evaluated the in vitro and in vivo properties of a novel liquid dermal scaffold in a delayed murine full thickness wound model. They compared this scaffold with two commercially- available granular collagen-based products

[Scientific Reports] Researchers investigated if α-tocopherol phosphate, a promising new antioxidant, could protect against long-wave UVA1 induced cell death and scavenge UVA1 induced reactive oxygen species in a skin cell model.

[Experimental Dermatology] The authors investigated the efficacy of the histone deacetylase inhibitor, Vorinostat, in targeting hyperproliferation and impaired apoptosis in psoriatic skin.

[Oncogene] Investigators reported that matrix metalloproteinase 9 (MMP-9) localized to the nucleus of melanoma cells and potentiated gene expression by proteolytically clipping the histone H3 N-terminal tail.

[Science Immunology] Researchers showed that mice having a keratinocyte-specific deletion of Fn14, the receptor for the tumor necrosis factor (TNF) superfamily cytokine TWEAK, displayed reduced imiquimod-induced skin inflammation, diminished epidermal hyperplasia and less expression of psoriasis signature genes.

[PLoS Biology] Investigators reported that the genetic and pharmacological inhibition of nicotinamide phosphoribosyltransferase (Nampt), the rate-limiting enzyme in the salvage pathway of NAD+ biosynthesis, reduced oxidative stress and cell death in zebrafish models of chronic skin inflammation.