dermal cells

[Cancer Research] Scientists studied proton radiotherapy (PRT) damage to skin and mesenchymal tissues of muscle and bone and found that flash PRT of the C57BL/6 murine hind leg produced fewer severe toxicities leading to death or requiring euthanasia than standard proton-PRT of the same dose.

[Cell and Tissue Research] Various factors were precisely modulated to facilitate differentiation of human iPSCs into dental epithelial cells, which are essential for the regeneration of functional teeth.

[EMBO Reports] The authors showed that dedifferentiation of melanocytic-type melanoma cells into mesenchymal-like cells and acquisition of tolerance to targeted therapies was achieved through chronic inhibition of CDK7.

[Oncology Reports] Scientists revealed that TβRI‑TβRII‑Fc chimeric receptor suppressed the epithelial‑mesenchymal transition program in melanoma cells in vitro induced by any of the three TGF‑β isoforms, as revealed by decreased expression of mesenchymal markers.

[Acta Biomaterialia] Severe injuries to skin including hypodermis require full-thickness skin replacement. Researchers bio-engineered a tri-layered human skin substitute containing the epidermis, dermis, and hypodermis.

[Redox Biology] The authors evaluated the effects of cannabidiol, a phytocannabinoid known for its antioxidant and anti-inflammatory properties, on the proteome of keratinocyte membranes exposed to hydrogen peroxide.