dermal cells

[Experimental Dermatology] The authors showed that protein phosphatase 2 A catalytic subunit α isoform (PP2Acα) negatively regulated epidermal growth factor receptor (EGFR) phosphorylation and epidermal cell proliferation, and EGFR inhibitors potentially alleviated PP2Acα by inhibiting epidermal cell proliferation.

[Inflammation] Investigators found that circular RNA OAS3 (circOAS3) expression was significantly upregulated in both psoriatic tissues and M5-induced keratinocytes.

[Molecular Pharmaceutics] MiR-155-inhibitor-loaded MSC-derived exosomes showed synergistic effects in keratinocyte migration, restoration of FGF-7 levels, and anti-inflammatory action, leading to accelerated wound healing mediated by negative regulation of miR-155, using an in vitro co-culture model and in vivo mouse model of the diabetic wound.

[Frontiers in Oncology] Investigators revealed that PLA2G6 was up-regulated in cutaneous malignant melanoma tissues compared to nevus tissues, as well as increased in vitro in SK-MEL-28 and M14 melanoma cell lines compared to human melanocytes.

[Clinical Rheumatology] Scientists investigated the structural and functional changes in the localized scleroderma (LSc) epidermis and further explored the underlying mechanisms, providing a new angle to treat LSc in the clinic.

[Journal of Biophotonics] Researchers evaluated cell viability, apoptosis rate, and reactive species injection efficiency of melanoma cells and human keratinocyte cells treated with cold atmospheric plasma and analyzed its biological safety.