PP2Acα Regulates Epidermal Cell Proliferation via the EGFR/AKT/mTOR Pathway in Psoriasis-Like Skin Lesions Caused by PPP2CA Deficiency

The authors showed that protein phosphatase 2 A catalytic subunit α isoform (PP2Acα) negatively regulated epidermal growth factor receptor (EGFR) phosphorylation and epidermal cell proliferation, and EGFR inhibitors potentially alleviated PP2Acα by inhibiting epidermal cell proliferation.