embryonic stem cells

[Journal of Cellular Biochemistry] MiR-1290 was discovered for the first time in human embryonic stem cells, and under typical physiological situations, plays an essential role in neuronal differentiation and neural stem cell proliferation.

[Epigenetics & Chromatin] Researchers determined whether GSK-3484862 can induce demethylation more effectively than 5-azanucleosides. They determined the cytotoxicity and optimal concentration of GSK-3484862 by treating wild-type or Dnmt1/3a/3b triple knockout mESC with different concentrations of the compound, which was obtained from two commercial sources.

[Toxicology] Scientists explored the toxic effects and mechanisms of trichloroethylene (TCE) on hESC proliferation. TCE exposure resulted in upregulation of Cx43 via Akt phosphorylation, consequently stimulated CDK2 expression, contributing to hyper-proliferation in hESCs.

[Nucleic Acids Research] Researchers showed that histone variant H3.3 actively marked enhancers and cooperated with H2A.Z at promoters to prime the genes into a poised state in mouse embryonic stem cells.

[Journal of Molecular Cell Biology] Based on the chemical screening, the authors developed a new recipe for efficient induction of progenitors of motor neurons progenitors from human embryonic stem cells.

[Neuroscience Letters] Before co-culture, Stem cells from human exfoliated deciduous teeth's (SHED) mitochondria and ESCs's cell membranes were separately labeled with specific fluorescent probes. After co-culture, SHED's mitochondria were tracked by fluorescent microscope and flow cytometry analysis.