Cx43 Overexpression Is Involved in the Hyper-Proliferation Effect of Trichloroethylene on Human Embryonic Stem Cells

Scientists explored the toxic effects and mechanisms of trichloroethylene (TCE) on hESC proliferation. TCE exposure resulted in upregulation of Cx43 via Akt phosphorylation, consequently stimulated CDK2 expression, contributing to hyper-proliferation in hESCs.