embryonic stem cells

[Nature Communications] Researchers showed that in pre-implantation embryos and naïve ESCs, hypomethylated promoters of germline genes bound by the PRC1.6 DNA-binding subunits MGA/MAX/E2F6 were enriched for RING1B-dependent H2AK119ub1 and H3K9me3.

[Nature Communications] The authors showed that SPEN played an important role in initiation of X chromosome inactivation. Spen null female mouse ESCs were defective in Xist upregulation upon differentiation.

[Scientific Reports] Scientists integrated genome-wide datasets of RNA-chromatin and promoter-genome interactions in human ESCs to identify putative RNA-mediated promoter interactions.

[Protein & Cell] Investigators showed that an unlimited number of oocytes could be derived from pparthenogenetic ESCs and produce healthy offspring.

[iScience] The authors revealed that the expression of thousands of genes in mouse ESCs was affected by cell seeding density and that low cell density enhanced the efficiency of differentiation.

[AgeX Therapeutics, Inc.] AgeX Therapeutics, Inc. announced that ImStem Biotechnology, Inc., a biopharmaceutical company developing human ESC-derived mesenchymal stem cells, has dosed the first US multiple sclerosis patient with ImStem’s lead investigational drug candidate IMS001.