Repression of Germline Genes by PRC1.6 and SETDB1 in the Early Embryo Precedes DNA Methylation-Mediated Silencing

Researchers showed that in pre-implantation embryos and naïve ESCs, hypomethylated promoters of germline genes bound by the PRC1.6 DNA-binding subunits MGA/MAX/E2F6 were enriched for RING1B-dependent H2AK119ub1 and H3K9me3.