embryonic stem cells

[Stem Cell Reviews and Reports] The authors generated NMPs from human ESCs, subsequently derived MSCs and characterized this cell population in vitro and in vivo. NMP-derived MSCs were plastic adherent fibroblast like cells with colony forming capacity and trilineage (osteo-, chondro- and adipo-genic) differentiation potential.

[Journal of Molecular and Cellular Cardiology] Scientists checked transcriptional profile by microarray and found Hippo pathway was changed and the activity of YAP decreased during mesoderm-mediated endothelial cell differentiation from human ESCs.

[iScience] Investigators optimized the in vitro liver fibrotic niches and subsequently harvested their bioactive ingredients as niche extracts

[Nature Communications] Scientists identified PHD-finger protein 3 (PHF3) as a regulator of transcription and mRNA stability that docked onto Pol II CTD through its SPOC domain. Key neuronal genes were aberrantly expressed in Phf3 knock-out mouse embryonic stem cells, resulting in impaired neuronal differentiation.

[Nature Communications] Scientists showed a role of guidance receptor Plexin-B2 in organizing actomyosin network and adhesion complexes during multicellular development of human embryonic stem cells and neuroprogenitor cells.

[Biology Open] Activation of activin A signaling stimulated NANOG expression during self-renewal of bovine ESC but suppressed cells expressing pluripotency markers in the blastocyst and increased cells expressing CDX2.