Trophoblast Glycoprotein Is a Marker for Efficient Sorting of Ventral Mesencephalic Dopaminergic Precursors Derived from Human Pluripotent Stem Cells-targeted cell sorting enriched FOXA2+LMX1A+ vmDA precursors and helped attain efficient behavioral recovery of rodent Parkinson’s disease models with increased numbers of TH+, NURR1+, and PITX3+ vmDA neurons in the grafts.
[npj Parkinson’s Disease]
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Researchers developed culture conditions to recreate the stepwise differentiation process from pluripotent cells to fetal ovarian somatic cell–like cells, providing a method for in vitro oocyte production and follicle generation for a better understanding of mammalian reproduction.
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The authors discuss how different translation mechanisms control the function of adult and embryonic stem cells.
[Nature Reviews Molecular Cell Biology]
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p53 activation convergently evolved to couple p53 to double homeobox (Dux)/DUX4 activation in ESCs, embryos and cells from patients with facioscapulohumeral muscular dystrophy (FSHD), potentially uniting the developmental and disease regulation of DUX-family factors and identifying evidence-based therapeutic opportunities for FSHD.
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A low-cost protocol for cardiomyocyte differentiation from mouse ESCs is presented and it is shown that Pten deletion potently suppressed cardiomyocyte differentiation.
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Investigators established directed differentiation models to generate tendon and fibrocartilage cells from mouse ESCs by activation of TGFβ and hedgehog pathways, achieving 90% induction efficiency.
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The authors showed that conditional Satb2 gene inactivation weakened ESC pluripotency, and identified SUMO2 modification of SATB2 by the E3 ligase ZFP451 as a potential driver of ESC differentiation.
[Genes & Development]
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The authors identified O-GlcNAcylation of proteasome activator subunit 3 (Psme3) protein as a node of the ESC pluripotency network. Mechanistically, O-GlcNAc modification of serine 111 (S111) of Psme3 promoted degradation of Ddx6, which was essential for processing body assembly, resulting in the maintenance of ESC pluripotent state.
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Human umbilical vein endothelial cells (HUVECs) elongated, activated TAGLN promoter and increased TAGLN transcripts in angiogenesis model. Genetic disruption of TAGLN augmented angiogenic behaviors of HUVECs, as did the disruption of TAGLN2 and TAGLN3 genes.
[Journal of Cell Science]
To study of the relationship between DMR methylation and imprinted gene expression, scientists differentiated wild-type and Zfp57-/- hybrid mouse ESCs into neural precursor cells and evaluated allelic expression of imprinted genes.
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JMJD3 has been found to enhance self-renewal ability and reduce the differentiation capacity of ESCs and multipotent stem cells. The authors discuss the recent advances of JMJD3 function in stem cell fate.
[Cell Communication and Signaling]
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