embryonic stem cells

[Frontiers in Cell and Developmental Biology] Based on the results of a bibliometric analysis of intestinal organoids applications, scientists systematically summarized the latest advances and analyzed the limitations and prospects.

[Oncogene] Scientists review how canonical functions of Enhancer of Zeste Homolog 2 as a histone methyltransferase activity are regulated and describe the various mechanisms of Polycomb Repressive Complex 2 recruitment to the chromatin.

[Stem Cell Reports] Scientists evaluated the efficacy of cryopreserved human embryonic stem cell-derived corneal endothelial cells to form a functional monolayer of corneal endothelium in rabbits and monkeys.

[Stem Cell Research] Scientists generated a homozygous KCNQ1 knockout human ESC line using episomal vector-based CRISPR/Cas9 system. This generated cell line presented typical stem cells colony morphology, maintained highly pluripotency and normal karyotype, also was able to differentiate into all three germ layers in vivo.

[Journal of Experimental & Clinical Cancer Research] Investigators discuss the role of hypoxia facilitating senescence bypass during malignant transformation and acquisition of stemness properties, which all contribute to tumor development and cancer disease aggressiveness.

[Journal of Cellular and Molecular Medicine] Investigators showed that endogenous stimuli and VEGF were sufficient to induce robust human pluripotent stem cell-derived hematopoiesis, intensive generation of hematopoietic progenitors, maturation of blood cells and the emergence of definitive precursor cells including those that were phenotypically identical to early human embryonic HSCs.