Recapitulative Hematopoietic Development of Human Pluripotent Stem Cells in the Absence of Exogenous Hematopoietic Cytokines

Investigators showed that endogenous stimuli and VEGF were sufficient to induce robust human pluripotent stem cell-derived hematopoiesis, intensive generation of hematopoietic progenitors, maturation of blood cells and the emergence of definitive precursor cells including those that were phenotypically identical to early human embryonic HSCs.