endothelial cells

[Journal of the American Society of Nephrology] The authors designed a non-human leukocyte antigen (HLA) antibody detection immunoassay using HLA class I and II–deficient glomerular endothelial cells that had been previously generated through CRISPR/Cas9-induced B2M and CIITA gene disruption.

[Hypertension Research] Hypoxia increased α1-AR and vascular endothelial growth factor (VEGF) mRNA levels in adipose-derived stem cells. Norepinephrine further increased VEGF mRNA expression under hypoxia; this effect was abolished by doxazosin.

[Cardiovascular Research] NOX1 mediated endothelial activation and contributed to myocardial inflammation and remodeling in metabolic disease in mice. Given its high expression in monocytes of humans with diastolic dysfunction (DD), NOX1 may represent a potential target to mitigate heart disease associated with DD.

[Nature Communications] Researchers reported that bone marrow (BM) vascular endothelial cells secreted semaphorin 3 A (SEMA3A) in response to myeloablation and SEMA3A induced p53 – mediated apoptosis in BM endothelial cells via signaling through its receptor, Neuropilin 1 (NRP1), and activation of cyclin dependent kinase 5.

[Nature Communications] Scientists showed that bone marrow sinusoidal endothelial cells (BM-SEC) actively controlled erythropoiesis. While activation of Wnt-signaling in BM-SEC caused an increase in erythroblast subsets, mature erythroid cells were reduced, indicating impairment of terminal erythroid differentiation/reticulocyte maturation.

[Science Advances] Endothelial cells subjected to ultralow shear stress could reposition inside the flowing lumen as pillars. Moreover, the low-flow lumen proved to be a privileged location for endothelial cells with reduced vascular endothelial growth factor receptor-2 (VEGFR2) signaling capacity, as VEGFR2 mechanosignals were boosted.