NOX1 Mediates Metabolic Heart Disease in Mice and Is Upregulated in Monocytes of Humans with Diastolic Dysfunction

NOX1 mediated endothelial activation and contributed to myocardial inflammation and remodeling in metabolic disease in mice. Given its high expression in monocytes of humans with diastolic dysfunction (DD), NOX1 may represent a potential target to mitigate heart disease associated with DD.