endothelial cells

[Aging] The authors investigated the effects of bone morphogenetic protein 9 on osteogenesis and angiogenesis of human amniotic mesenchymal stem cells (hAMSCs) cocultured with human umbilical vein endothelial cells (HUVECs) and determined the possible underlying molecular mechanism.

[Journal of Cardiovascular Pharmacology] The authors provide a summary on the regulation and function of SIRT1 in the vascular endothelium and discuss the different approaches targeting this molecule for the prevention and treatment of age-related cardiovascular and cerebrovascular diseases.

[Nature Reviews Gastroenterology & Hepatology] Scientists summarize the role of macrophages, platelets and neutrophils in liver ischaemia–reperfusion injury (LIRI), highlight unanswered questions, and discuss prospects for innovative therapeutic regimens against LIRI in transplant recipients.

[Nature Cancer] Scientists found that small extracellular vesicles derived from metastatic melanoma cell lines were enriched in nerve growth factor receptor, spread through the lymphatic system and were taken up by lymphatic endothelial cells, reinforcing lymph node metastasis.

[Proceedings of the National Academy of Sciences of the United States of America] The authors demonstrated that vitexin, a natural flavonoid, could inhibit the activation of apurinic/apyrimidinic endonuclease1 (APEX1) to protect vascular endothelium against the adverse effects of atherogenic stimuli.

[Proceedings of the National Academy of Sciences of the United States of America] Investigators revealed that IκB kinase (IKK)-α in distinct endothelial cell (EC)-derived compartments was uniquely required to promote B cell homeostasis and lymph node (LN) development, and they established that lymphatic EC-intrinsic IKK-α was absolutely essential for LN formation.